Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Uniform pulsed fields for ultrasonic bioeffect experimentation.

G H Harrison1, E K Balcer-Kubiczek

  • 1Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore 21201.

Ultrasonics
|May 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Molecular markers of apoptosis in cancer patients exposed to ionizing radiation: the post-Chornobyl view.

Experimental oncology·2017
Same author

Apoptosis in radiation therapy: a double-edged sword.

Experimental oncology·2012
Same author

Delayed expression of hpS2 and prolonged expression of CIP1/WAF1/SDI1 in human tumour cells irradiated with X-rays, fission neutrons or 1 GeV/nucleon Fe ions.

International journal of radiation biology·2001
Same author

Survival of colorectal cancer cell lines treated with paclitaxel, radiation, and 5-FU: effect of TP53 or hMLH1 deficiency.

International journal of cancer·2000
Same author

Expression analysis of human HL60 cells exposed to 60 Hz square- or sine-wave magnetic fields.

Radiation research·2000
Same author

BIGEL analysis of gene expression in HL60 cells exposed to X rays or 60 Hz magnetic fields.

Radiation research·1998

Researchers developed a method to generate high-amplitude pulsed ultrasound fields. These uniform fields are ideal for studying diagnostic ultrasound

Area of Science:

  • Biomedical Engineering
  • Acoustics
  • Ultrasound Technology

Background:

  • Diagnostic ultrasound utilizes pulsed fields.
  • Understanding bioeffects and therapeutic potential requires controlled ultrasound exposure.
  • Previous methods lacked uniform high-amplitude field generation.

Purpose of the Study:

  • To present methods for producing high-amplitude pulsed ultrasound fields.
  • To ensure uniform pressure distribution over several square centimeters.
  • To enable bioeffect and therapeutic application research.

Main Methods:

  • Utilized high power pulsers and minimally damped 3.8 cm diameter transducers.
  • Generated pulsed fields with specific parameters (e.g., 1 MPa, 1-9 pulses/burst, up to 10^4 bursts/sec, 1-3.5 MHz).

Related Experiment Videos

  • Measured waveforms and negative pressure distributions in water.
  • Main Results:

    • Achieved high-amplitude pulsed ultrasound fields.
    • Demonstrated uniform lateral pressure distributions within +/- 15% over areas up to 4 cm^2.
    • Displayed waveforms and negative pressure distributions.

    Conclusions:

    • The developed method produces uniform, high-amplitude pulsed ultrasound fields.
    • These fields are suitable for bioeffect studies on diagnostic ultrasound.
    • The fields can be applied to investigate therapeutic ultrasound applications.