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Related Experiment Video

Updated: Jun 14, 2026

Tricolor Transgenic Murine Model for Studying Growth Plate Injury

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Published on: September 6, 2024

Metaphyseal bands in osteogenesis imperfecta.

Ss Suresh¹, John K Thomas

¹Department of Orthopaedics, Ibri Regional Referral Hospital, PO Box 46, Ibri 516, Al-Khod, Sultanate of Oman.

The Indian Journal of Radiology & Imaging

|March 31, 2010

Summary

Pamidronate therapy is used to prevent fractures in osteogenesis imperfecta. A 3-year-old child developed metaphyseal "zebra lines" after five cycles of this treatment.

Keywords:

Osteogenesis imperfecta pamidronate zebra lines

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Area of Science:

Pediatric Endocrinology
Skeletal Dysplasias
Pharmacology

Background:

Osteogenesis imperfecta (OI) is a genetic disorder characterized by fragile bones.
Bisphosphonates, such as pamidronate, are increasingly used to manage OI and reduce fracture risk.
Effective management of OI aims to improve bone density and prevent skeletal morbidity.

Observation:

A pediatric case study involving a 3-year-old child diagnosed with osteogenesis imperfecta.
The patient received multiple cycles of intravenous pamidronate therapy.
Radiographic examination was performed to monitor treatment effects and bone health.

Findings:

Treatment with pamidronate resulted in the appearance of distinct metaphyseal bands, or "zebra lines," on radiographic imaging.
These "zebra lines" represent a characteristic radiographic finding associated with bisphosphonate therapy in pediatric patients.
The observation highlights a specific radiological sign linked to pamidronate administration in young children with OI.

Implications:

The findings contribute to understanding the radiographic manifestations of pamidronate treatment in pediatric osteogenesis imperfecta.
Recognition of "zebra lines" is crucial for accurate interpretation of skeletal imaging in children undergoing bisphosphonate therapy.
This case underscores the importance of correlating clinical treatment with radiological findings for comprehensive patient care.