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Updated: Jun 14, 2026

A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome

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Published on: October 2, 2018

Persistent mullerian duct syndrome.

Divya Renu¹, B Ganesh Rao, K Ranganath

¹Department of Radiodiagnosis, RAGAVS Diagnostic and Research Centre Pvt Ltd, Sadguru Complex, No.14, 27 Cross, 4 Block West, Jayanagar, Bangalore - 560 011, India.

The Indian Journal of Radiology & Imaging

|March 31, 2010

Summary

This summary is machine-generated.

Persistent Mullerian duct syndrome (PMDS) is a rare condition where males develop female internal reproductive organs. This case highlights imaging features of PMDS with associated conditions like cryptorchidism and inguinal hernia.

Keywords:

Cryptorchidism MRI USG inguinal hernia mullerian duct derivatives mullerian inhibiting factor pseudohermaphroditism

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Area of Science:

Reproductive Endocrinology
Medical Imaging
Pediatric Surgery

Background:

Persistent Mullerian duct syndrome (PMDS) is a rare intersex condition.
Characterized by the presence of Mullerian duct derivatives (uterus, cervix, fallopian tubes, upper vagina) in a male individual.
This occurs due to mutations in genes like AMH or AMHR2, affecting Mullerian duct regression.

Observation:

Presents a case of PMDS in a phenotypically and karyotypically male patient.
The patient exhibited bilateral cryptorchidism and a left-sided inguinal hernia.
Imaging studies, including Ultrasound (USG) and Magnetic Resonance Imaging (MRI), were crucial for diagnosis.

Findings:

USG and MRI clearly visualized the persistent Mullerian structures within the male pelvis.
Demonstrated the presence of a uterus, cervix, and fallopian tubes.
Correlated imaging findings with clinical presentation of cryptorchidism and inguinal hernia.

Implications:

Highlights the importance of imaging in diagnosing PMDS, especially when associated with other congenital anomalies.
Accurate diagnosis aids in surgical planning for managing cryptorchidism and hernia, while considering the presence of Mullerian remnants.
Contributes to understanding the spectrum of PMDS and its management in pediatric cases.