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09:04
A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors
Published on: March 15, 2016
VEGF gene polymorphism association with diabetic neuropathy
Javad Tavakkoly-Bazzaz1, Mahsa M Amoli, Vera Pravica
1Endocrinology and Metabolism Research Center, Dr Shariati Hospital, Tehran University of Medical Sciences, North Karegar St., Tehran, 14114, Iran. tavakkolybazzazj@tums.ac.ir.
Molecular Biology Reports
|March 31, 2010
Summary
A specific gene variant in vascular endothelial growth factor (VEGF) is linked to diabetic neuropathy (DNU) risk in type 1 diabetes. The VEGF -7*C/T polymorphism may influence DNU development.
Area of Science:
- Genetics
- Diabetology
- Neurology
Background:
- Diabetic neuropathy (DNU) involves vascular and metabolic factors.
- Vascular endothelial growth factor (VEGF) plays a role in blood vessel repair during DNU.
- VEGF's angiogenic and hemodynamic functions are crucial for tissue healing.
Purpose of the Study:
- To investigate the association between VEGF gene polymorphisms and diabetic neuropathy in type 1 diabetes.
- To determine if specific VEGF gene variants influence susceptibility to DNU.
Main Methods:
- Analyzed VEGF gene polymorphisms (-7*C/T, -1001*G/C, -1154*G/A, -2578*C/A) using ARMS-PCR.
- Studied 248 British-Caucasian subjects with type 1 diabetes (81 DNU+, 167 DNU-).
Main Results:
- A significant difference in VEGF gene polymorphism distribution at -7*C/T was observed between DNU+ and DNU- groups.
- The 'C' allele at the -7*C/T position conferred susceptibility to DNU (P = 0.02; OR = 1.78).
Conclusions:
- The VEGF gene polymorphism at position -7*C/T may be implicated in the pathogenesis of diabetic neuropathy.
- This polymorphism might have functional or regulatory potential affecting VEGF gene expression.
- Further research is needed to understand its phenotypic impact and prognostic value in DNU.
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