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Related Concept Videos

COP Coated Vesicles00:59

COP Coated Vesicles

Membrane-enclosed structures called vesicles transport proteins and lipids across the cell. The vesicles derive their cargo from the plasma membrane, Golgi, ER, or endosome. Coated vesicles are spherical, protein-coated carriers with a 50–100 nm diameter that mediate bidirectional transport between the ER and the Golgi. The distribution of proteins between the ER and Golgi complex is dynamic and is maintained by different coated vesicles. Their formation is driven by the assembly of different...
Overview of Secretory Vesicles01:33

Overview of Secretory Vesicles

Secretory vesicles, also known as dense core vesicles (DCVs), are membrane-bound vesicles that transport secretory proteins, such as hormones or neurotransmitters. Regulated secretory vesicles transport proteins from the trans-Golgi network to the exterior of the cell. Proteins present in regulated secretory vesicles are required to be rapidly exocytosed in large amounts upon a specific stimulus.
Various proteins regulate the aggregation of molecules inside the secretory vesicles. Chromogranins...
Pinching-off of Coated Vesicles01:32

Pinching-off of Coated Vesicles

Vesicle budding is orchestrated by distinct cytosolic proteins such as adaptor proteins, coat proteins, and GTPases. To initiate vesicle budding, membrane-bending proteins containing crescent-shaped BAR domains bind to the lipid heads in the bilayer and distort the membrane to form a protein-coated vesicle bud. Adaptors proteins such as AP2 for clathrin-coated vesicles can nucleate on the deformed membrane. Finally, coat proteins such as clathrin or COPI and COPII assemble into a coat forming...
Clathrin Coated Vesicles01:12

Clathrin Coated Vesicles

Clathrin-coated vesicles use endocytosis to transport receptors and lysosomal hydrolases from the Golgi to the lysosome in the late secretory pathway. Clathrin-mediated endocytosis was the first described endocytic process, and Clathrin-coated vesicles remain one of the most well-studied transport vesicles. The molecular machinery that generates clathrin-coated vesicles comprises over 50 proteins that precisely coordinate vesicle formation. Cell surface receptors concentrated in indented sites...
Introduction to Membrane Traffic01:44

Introduction to Membrane Traffic

The ER, Golgi apparatus, endosomes, and lysosomes work in tandem to modify, sort, and package proteins and lipids. An integrated membrane trafficking network facilitates the back and forth shuttling of molecules within different organelles in the same cell or across the cell membrane.
The transport of soluble and membrane proteins is mediated by transport vesicles that collect cargo from one cellular compartment and deliver it to another by fusing with the target organelle membrane. The Rab...
Fusion of Secretory Vesicles with the Plasma Membrane01:26

Fusion of Secretory Vesicles with the Plasma Membrane

Proteins and neurotransmitters in secretory vesicles can be released from a cell upon vesicle docking, priming, and fusion with the plasma membrane. Vesicles are docked and primed in preparation for the quick exocytosis of their contents in response to a stimulus. The fusion process is mainly carried out by a SNAP Receptor or SNARE complex, consisting of synaptobrevin, syntaxin-1, and SNAP-25.
In 1993, Jim Rothman proposed that the antiparallel pairing of vesicular and transmembrane SNAREs, or...

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Related Experiment Video

Updated: Jun 14, 2026

Preparation of Functional Silica Using a Bioinspired Method
08:04

Preparation of Functional Silica Using a Bioinspired Method

Published on: August 1, 2018

A bioinspired route to various siliceous vesicular structures.

Meihua Yu1, Pei Yuan, Jun Zhang

  • 1Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Shanghai, 200433, PR China.

Journal of Nanoscience and Nanotechnology
|April 1, 2010
PubMed
Summary

Researchers synthesized diverse silica nanostructures using a biodegradable block copolymer and silica source under mild pH. This bioinspired method creates tunable nanoporous materials with varied morphologies for potential applications in catalysis and beyond.

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Preparation of Functional Silica Using a Bioinspired Method
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Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomimetic Chemistry

Background:

  • Biomineralization processes inspire the creation of novel materials.
  • Controlling silica nanostructure morphology is crucial for advanced applications.

Purpose of the Study:

  • To develop a convenient, bioinspired route for synthesizing tunable siliceous nanostructures.
  • To explore the influence of reaction parameters on nanostructure morphology and pore characteristics.

Main Methods:

  • Utilized a biodegradable block copolymer (P123) as a templating agent.
  • Employed sodium silicate (Na2SiO3·9H2O) as the silica source.
  • Synthesized nanostructures under mild pH conditions (pH ~5) by adjusting reactant concentrations and temperature.

Main Results:

  • Successfully synthesized various siliceous nanostructures, including multilamellar vesicles and nano-foams.
  • Achieved tunable, multi-level pore structures and diverse morphologies.
  • Demonstrated control over nanostructure formation by varying synthesis conditions.

Conclusions:

  • The study presents a facile, bioinspired method for producing advanced silica nanoporous materials.
  • The synthesized materials exhibit adjustable properties and rich morphologies, aiding biomineralization mechanism understanding.
  • Potential applications exist in catalysis, separations, electronics, and photonics.