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Related Experiment Video

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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

The endocannabinoid system and migraine.

Rosaria Greco¹, Valeria Gasperi, Mauro Maccarrone

¹Headache Science Centre, IRCCS Neurological Institute C. Mondino Foundation, Pavia, Italy.

Experimental Neurology

|April 1, 2010

Summary

The endocannabinoid system (ECS) plays a role in pain signaling. Activating the ECS shows promise for treating migraine pain by reducing physiological and inflammatory components.

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Area of Science:

Neuroscience
Pharmacology

Background:

The endocannabinoid system (ECS) regulates physiological functions.
The ECS is involved in processing pain signals both centrally and peripherally.
Endocannabinoids inhibit neurotransmitter release via cannabinoid type-1 receptors (CB1R).

Purpose of the Study:

To review experimental and clinical data linking the ECS to migraine.
To explore the potential of ECS activation as a therapeutic strategy for migraine.

Main Methods:

Review of existing experimental and clinical studies.
Analysis of data on endocannabinoid levels and CB1R mechanisms in pain pathways.

Main Results:

Endocannabinoids are implicated in pain signal processing.
High levels of endocannabinoids are found in pain-associated regions.
Evidence suggests a link between the ECS and migraine pathophysiology.

Conclusions:

The ECS is involved in the neurovascular disorder of migraine.
ECS activation may offer a therapeutic approach for migraine pain.
Further research is needed to fully understand ECS-dependent mechanisms in migraine.