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Updated: Jun 14, 2026

A Luciferase-fluorescent Reporter Influenza Virus for Live Imaging and Quantification of Viral Infection
Published on: August 14, 2019
[Epidemiology of influenza A (H1N1) worldwide and in Spain]
1Servicio de Medicina Preventiva y Epidemiología, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, España. jvaque@vhebron.net
Abstract:
On June 11, 2009, the World Health Organization declared an established pandemic due to a new influenza virus A (H1N1) of swine origin. Initial cases were detected in Mexico in March and within 6 weeks the virus had spread worldwide. The transmissibility of influenza A (H1NA) is slightly higher than that of the seasonal virus, but its pathogenicity and virulence are low. The main target groups of this new virus have been children and young adults under 30 years old. Mortality has affected mainly persons aged between 20 and 50 years old. In areas with temperate climates, two epidemic waves have occurred. The first one, from mid-April to mid-August, affected Mexico, the United States and, consecutively, Spain, England, Japan, and other countries in the northern hemisphere. A few weeks later, coinciding with the beginning of the influenza season, the H1N1 epidemic started in the southern hemisphere countries, especially Argentina, Chile, Australia and New Zealand; in these countries, the epidemic finished at the end of September or October. The second wave affected the northern hemisphere, starting in the United States and Mexico at the beginning of September, and a few weeks later in European countries. In mid-December, this wave was considered to have ended, although some influenza activity persists. The intensity of this second wave was higher compared to the first one.
Insights
The 2009 H1N1 swine flu pandemic spread globally, with two waves impacting temperate regions. This influenza A (H1N1) virus showed low pathogenicity but affected younger populations.
Area of Science:
- Virology
- Epidemiology
Context:
- The World Health Organization declared a pandemic in June 2009 due to a novel influenza A (H1N1) virus of swine origin.
- The virus rapidly spread worldwide from initial detections in Mexico.
Purpose:
- To describe the epidemiology and characteristics of the 2009 influenza A (H1N1) pandemic.
- To analyze the transmissibility, pathogenicity, and demographic impact of the H1N1 virus.
Summary:
- Influenza A (H1N1) exhibited slightly higher transmissibility than seasonal flu but low pathogenicity and virulence.
- The virus primarily targeted children and young adults, with mortality concentrated in those aged 20-50.
- Two distinct epidemic waves occurred in temperate climates, with the second wave being more intense.
Impact:
- Understanding the H1N1 pandemic's spread and impact is crucial for future public health preparedness.
- The study highlights the importance of monitoring novel influenza strains and their global dissemination.
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