Sialadenoma papilliferum with potentially malignant features

Area of Science:

• Oral pathology
• Oncology
• Surgical pathology

Background:

• Sialadenoma papilliferum (SP) is generally characterized as a benign, slow-growing salivary gland tumor.
• Its typical presentation involves limited intraoral growth without invasive characteristics.

Observation:

• This report details an atypical SP case with rapid, extensive intraoral tumor growth.
• The lesion exhibited significant mandibular bone resorption, mimicking verrucous carcinoma.
• Histological examination revealed unusual features, including surface verrucous hyperplasia and florid cystic-duct adenoma.

Findings:

• The observed destructive growth pattern and atypical histology suggest SP may represent a borderline lesion with malignant potential.
• This case diverges significantly from previously documented SP presentations and associated malignancies.
• The findings complicate the understanding of malignant transformation in SP.

Implications:

• This case underscores the importance of thorough histopathological evaluation for accurate diagnosis and prognosis of salivary gland tumors.
• It prompts re-evaluation of the classification and malignant potential of Sialadenoma papilliferum.
• Further research is needed to clarify the spectrum of SP behavior and its relationship to malignancy.