Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Does intravenous milrinone have a direct effect on diastolic function?

R Krams1, E McFalls, W J van der Giessen

  • 1Division of Cardiology, University Hospital Rotterdam, The Netherlands.

American Heart Journal
|June 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Aetiologies of lithium overdose: 10-year experience of Marseille poison centre].

Annales francaises d'anesthesie et de reanimation·2003
Same author

Ion-exchange column chromatographic method for assaying purine metabolic pathway enzymes.

Journal of chromatography. B, Biomedical sciences and applications·1998
Same author

Clinical application and image interpretation in intracoronary ultrasound. Study Group on Intracoronary Imaging of the Working Group of Coronary Circulation and of the Subgroup on Intravascular Ultrasound of the Working Group of Echocardiography of the European Society of Cardiology.

European heart journal·1998
Same author

Coronary bypass grafting for single-vessel coronary artery disease: a 17-year review with short- and long-term follow-up.

Chest·1998
Same author

Influence of heart rate, respiration and recipient atrial contraction on pulsed wave transmitral Doppler flow indices in orthotopic heart transplant recipients.

European heart journal·1997
Same author

Perforation of chronic total occlusion with laser guide wire followed by multiple stent deployment: usefulness of three-dimensional intracoronary ultrasound guidance.

American heart journal·1995
Same journal

Efficacy and safety of human albumin combined with furosemide in acute decompensated heart failure with hepatic dysfunction.

American heart journal·2026
Same journal

International study of Coronary Microvascular Angina (iCorMicA): a registry-based diagnostic study and nested randomized trial.

American heart journal·2026
Same journal

Stratified Medicine with Eplerenone for Myocardial Infarction or Injury and No obstructive Coronary Arteries: A Registry-Based Basket Trial.

American heart journal·2026
Same journal

Revised Lipid-Lowering Therapy Guidelines in a Nationally Representative Sample.

American heart journal·2026
Same journal

Cardiometabolic Health of Low- and Higher-Income Adults in the United States, 2009-2023.

American heart journal·2026
Same journal

Moving Beyond Technical Capability to Regulatory Integration for Digital Health Technology Devices-Brief Communication from the Cardiovascular Sciences Research Consortium.

American heart journal·2026
See all related articles

Milrinone, a bipyridine inodilator, improves heart function by affecting systolic and diastolic properties. Understanding factors influencing the left ventricular diastolic pressure-volume relationship is crucial for accurate assessment.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Bipyridine derivatives represent a novel class of inodilator drugs for intravenous heart failure therapy.
  • Milrinone, a bipyridine, enhances contractility and reduces afterload, improving hemodynamic function.
  • Systolic and diastolic cardiac functions are interconnected, suggesting milrinone's impact on diastolic properties.

Purpose of the Study:

  • To investigate the influence of milrinone therapy on left ventricular diastolic muscle properties.
  • To identify and differentiate static and dynamic factors affecting the left ventricular diastolic pressure-volume relationship during milrinone treatment.

Main Methods:

  • Measurement of the complete left ventricular diastolic pressure-volume (LVDPV) relationship.
  • Analysis of static factors (coronary vascular bed volume, right ventricular pressure, pericardial pressure) influencing the LVDPV relationship.

Related Experiment Videos

  • Evaluation of dynamic factors (viscoelasticity, myocardial active relaxation) affecting the LVDPV relationship.

    • Main Results:

    • Changes in end-diastolic pressure can occur due to volume shifts alone, necessitating a full LVDPV assessment.
    • Static factors like increased coronary perfusion pressure can stiffen the cardiac wall.
    • Dynamic factors such as viscoelasticity and abnormal relaxation are significant in isolated cardiac cycle assessments.

    Conclusions:

    • Accurate assessment of diastolic function requires a comprehensive understanding of the LVDPV relationship.
    • External factors (static) and intrinsic cardiac cycle dynamics (dynamic) must be considered when evaluating diastolic performance.
    • Clinical models often oversimplify cardiac mechanics by treating the heart as purely elastic, neglecting its viscoelastic nature.