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Updated: Jun 14, 2026

Quantifying Cognitive Decrements Caused by Cranial Radiotherapy
Published on: October 18, 2011
Radiotherapy: Neurocognitive considerations in the treatment of brain metastases
Nicholas F Marko1, Robert J Weil
1Department of Neurosurgery, The Brain Tumor and Neuro-Oncology Center, Cleveland Clinic, ND-40, 9500 Euclid Avenue, Cleveland, OH 44195, USA. markon@ccf.org
Abstract:
The results of a randomized, controlled trial investigating the neurocognitive effects of stereotactic radiosurgery (SRS), with or without whole-brain radiation therapy (WBRT), to treat brain metastases demonstrated a significant reduction in learning and memory, associated with the addition of WBRT to SRS. the results indicate that SRS monotherapy is an effective and safe initial management strategy for brain metastases.
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