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Minimally invasive colorectal resection for cancer is associated with a short-lived decrease in soluble Tie-2

H M C Shantha Kumara1, Michael J Grieco, Xiaohong Yan

  • 1Division of Colon and Rectal Surgery, Department of Surgery, St. Luke's-Roosevelt Hospital Center, Suite 7B, 425 West 59th Street, New York, NY 10019, USA. hmsach_6@yahoo.com

Surgical Endoscopy
|April 1, 2010
PubMed
Abstract

Insights

Preoperative plasma soluble Tie-2 (sTie-2) levels were lower in cancer patients undergoing minimally invasive colorectal resection (MICR). Postoperative levels decreased significantly in cancer patients, potentially inhibiting angiogenesis.

Area of Science:

  • Vascular biology
  • Oncology
  • Surgical research

Background:

  • Angiopoietin-1 (Ang-1) inhibits and Angiopoietin-2 (Ang-2) promotes VEGF-mediated angiogenesis via Tie-2 receptor binding.
  • Minimally invasive colorectal resection (MICR) alters Ang-1 and Ang-2 levels, potentially influencing angiogenesis in surgical sites and tumors.
  • Soluble Tie-2 (sTie-2) acts as a decoy receptor, modulating Ang-1 and Ang-2 activity.

Purpose of the Study:

  • To assess perioperative plasma levels of soluble Tie-2 (sTie-2) in patients undergoing MICR.
  • To compare sTie-2 levels between cancer and benign disease patients.
  • To investigate the dynamic changes in sTie-2 levels during the perioperative period.

Main Methods:

  • Blood samples collected preoperatively (PreOp) and on postoperative days (POD) 1 and 3 from 50 cancer and 53 benign disease MICR patients.
  • A subgroup had a fourth sample taken between POD7 and POD13.
  • Plasma sTie-2 levels were quantified using ELISA, with statistical analysis performed using the t-test.

Main Results:

  • PreOp sTie-2 levels were significantly lower in the cancer group (22.9 ± 7.9 ng/ml) compared to the benign group (27.6 ± 10.2 ng/ml).
  • A significant drop in sTie-2 levels was observed on POD1 and POD3 in the cancer group, and on POD1 in the benign group.
  • sTie-2 levels in the benign group on POD7-13 were significantly higher than PreOp levels, while cancer group levels on POD7-13 were similar to PreOp.

Conclusions:

  • Preoperative sTie-2 levels are significantly lower in cancer patients undergoing MICR.
  • MICR is associated with a transient, significant decrease in plasma sTie-2 levels in cancer patients on POD1 and 3.
  • This short-lived reduction in sTie-2 may temporarily inhibit VEGF-mediated angiogenesis following colorectal resection.

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