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Updated: Jun 14, 2026

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation
10:01

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation

Published on: July 10, 2012

Lung transplantation for advanced bronchiectasis.

Don Hayes1, Keith C Meyer

  • 1Departments of Pediatrics, Internal Medicine, and Surgery, University of Kentucky College of Medicine, Lexington, Kentucky, USA.

Seminars in Respiratory and Critical Care Medicine
|April 1, 2010
PubMed
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Lung transplant (LT) offers good outcomes for advanced bronchiectasis patients. While infections are common, they typically do not impact survival, though resistant bacteria pose challenges.

Area of Science:

  • Pulmonology
  • Transplant Surgery

Background:

  • Bronchiectasis is a chronic lung disease often associated with recurrent infections.
  • Lung transplantation (LT) is a potential treatment for end-stage lung disease.
  • Existing data primarily focuses on lung transplantation for cystic fibrosis (CF).

Purpose of the Study:

  • To review the role of lung transplantation in patients with bronchiectasis.
  • To discuss indications, contraindications, and post-transplant management challenges.
  • To provide a rationale for referring bronchiectasis patients for LT.

Main Methods:

  • Review of existing literature on lung transplantation for bronchiectasis.
  • Analysis of outcomes in patients with cystic fibrosis and non-CF bronchiectasis.
  • Discussion of pre- and post-transplant infectious complications.

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Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation
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Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation

Published on: July 10, 2012

Orthotopic Left Lung Transplantation in Rats
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Orthotopic Left Lung Transplantation in Rats

Published on: July 3, 2025

Main Results:

  • Lung transplantation can lead to good quality of life and long-term survival in patients with advanced bronchiectasis.
  • LT is effective for both CF and non-CF bronchiectasis, particularly in older children and adults.
  • Post-transplant infections generally do not significantly affect survival, but antibiotic-resistant bacteria can complicate management.

Conclusions:

  • Lung transplantation is a viable option for select patients with advanced bronchiectasis.
  • Careful patient selection and management of infections are crucial for successful outcomes.
  • LT offers significant benefits for older children and adults with severe bronchiectasis.