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Improving 2D and 3D Skin In Vitro Models Using Macromolecular Crowding
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Published on: August 22, 2016

Macromolecular crowding induces polypeptide compaction and decreases folding cooperativity.

Douglas Tsao1, Nikolay V Dokholyan

  • 1Department of Chemistry, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.

Physical Chemistry Chemical Physics : PCCP
|April 2, 2010
PubMed
Summary

Cellular crowding significantly impacts protein folding. Simulations show that macromolecules increase protein compaction but hinder cooperative folding, potentially trapping proteins in non-native states.

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