Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jun 14, 2026

Fluorescent Nanoparticles for the Measurement of Ion Concentration in Biological Systems

Fluorescent Nanoparticles for the Measurement of Ion Concentration in Biological Systems

Published on: July 4, 2011

Fluorescent nano-optodes for glucose detection.

Kelvin Billingsley¹, Mary K Balaconis, J Matthew Dubach

¹Biomedical Engineering Group, The Charles Stark Draper Laboratory, 555 Technology Square, Cambridge, Massachusetts 02139, USA.

Analytical Chemistry

|April 2, 2010

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

In vivo bacteria-targeted imaging with vancomycin-based positron emission tomography and optical tracers in an orthopaedic trauma implant infection model.

European journal of nuclear medicine and molecular imaging·2026

Same author

Spinal Implant-Associated Infection in Type 2 and Type 1 Diabetes: Phenotype-Specific Inflammatory Features and Therapeutic Response to Semaglutide.

JOR spine·2026

Same author

Pinhole engineering based enhanced resolution (PEER) for fluorescence lifetime imaging microscopy.

Communications biology·2026

Same author

Clinically Feasible Approaches to the Real-Time Measurement of Drugs, Metabolites, and Biomarkers in the Living Body.

Annual review of biomedical engineering·2026

Same author

A field polymerizing hydrogel enables simultaneous antimicrobial, hemostatic, and analgesic delivery in traumatic wounds.

Scientific reports·2026

Same author

Single-aperture SLAM microscopy with amplitude-tailored vector beams.

bioRxiv : the preprint server for biology·2025

Researchers developed novel fluorescent nanosensors for detecting small molecules like glucose. These sensors show promise for minimally invasive glucose monitoring in diabetes research and beyond.

Area of Science:

Biomedical Engineering
Analytical Chemistry
Nanotechnology

Background:

Small molecule detection is crucial for physiological monitoring.
Existing methods for glucose monitoring can be invasive.
Ion-selective optodes are established sensing platforms.

Purpose of the Study:

To design and validate fluorescent nanosensors for small molecule detection.
To assess the nanosensors' ability to monitor glucose dynamics in vitro and in vivo.
To establish a minimally invasive tool for glucose level monitoring.

Main Methods:

Development of fluorescent nanosensors with ion-selective optodes.
Localization of sensor components within a hydrophobic core.
In vitro and subcutaneous in vivo testing in mice.

More Related Videos

NiO Nanoflowers for Non-Enzymatic Amperometric Detection of Glucose

NiO Nanoflowers for Non-Enzymatic Amperometric Detection of Glucose

Published on: December 30, 2025

Highly Sensitive and Rapid Fluorescence Detection with a Portable FRET Analyzer

Highly Sensitive and Rapid Fluorescence Detection with a Portable FRET Analyzer

Published on: October 1, 2016

Related Experiment Videos

Last Updated: Jun 14, 2026

Fluorescent Nanoparticles for the Measurement of Ion Concentration in Biological Systems

Fluorescent Nanoparticles for the Measurement of Ion Concentration in Biological Systems

Published on: July 4, 2011

NiO Nanoflowers for Non-Enzymatic Amperometric Detection of Glucose

NiO Nanoflowers for Non-Enzymatic Amperometric Detection of Glucose

Published on: December 30, 2025

Highly Sensitive and Rapid Fluorescence Detection with a Portable FRET Analyzer

Highly Sensitive and Rapid Fluorescence Detection with a Portable FRET Analyzer

Published on: October 1, 2016

Comparison of nanosensor response with a standard glucometer.

Main Results:

Nanosensors successfully detected and monitored dynamic changes in glucose concentration.
The in vivo response in mice correlated well with blood glucose levels measured by a glucometer.
The nanosensors provided a minimally invasive method for glucose monitoring.

Conclusions:

Fluorescent nanosensors based on ion-selective optodes are effective for small molecule detection.
These nanosensors offer a viable, minimally invasive alternative for glucose monitoring.
The platform can be extended for monitoring other physiological small molecules.