Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jun 14, 2026

Microfluidic Fabrication of Core-Shell Microcapsules carrying Human Pluripotent Stem Cell Spheroids

Microfluidic Fabrication of Core-Shell Microcapsules carrying Human Pluripotent Stem Cell Spheroids

Published on: October 13, 2021

"Giant" hollow multilayer capsules by microfluidic templating.

M Talha Gokmen¹, Bruno G De Geest, Wim E Hennink

¹Polymer Chemistry Research Group, Department of Organic Chemistry, and Department of Pharmaceutics, Ghent University, 9000 Ghent, Belgium.

ACS Applied Materials & Interfaces

|April 2, 2010

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Muscle macrophage regenerative response after squalene-adjuvanted influenza vaccination is associated with type II-skewed response and is reduced with age.

NPJ vaccines·2026

Same author

Highly robust molecular information carriers for traceability of plastic materials.

Nature communications·2026

Same author

POLY-Senolytic nanoplatform for tumor-specific eradication of senescent tumor cells and mitigation of radiotherapy-induced immune resistance of cancer.

Nature communications·2026

Same author

Tailoring fully biobased optical adhesives <i>via</i> hydrogen-bonding modulation.

RSC applied polymers·2026

Same author

Spatiotemporal Nanotransformers for Antitumoral Orchestration of Protein Homeostasis.

Polymer science & technology (Washington, D.C.)·2026

Same author

Multivalent Antibody-Recruiting Molecules for Targeted Immune-Killing of Carbonic Anhydrase IX-Expressing Cancer Cells.

Angewandte Chemie (International ed. in English)·2026

Researchers created large, hollow polyelectrolyte capsules using microfluidic-synthesized microgels as sacrificial templates. These robust capsules, featuring cross-linked polymers and platinum nanoparticles, show potential for microreactors and drug delivery.

Area of Science:

Materials Science
Nanotechnology
Polymer Chemistry

Background:

Microfluidic techniques enable precise control over particle synthesis.
Sacrificial templating is a key strategy for creating hollow nanostructures.
Polyelectrolyte capsules offer versatile platforms for encapsulation and delivery.

Purpose of the Study:

To develop a method for fabricating "giant" hollow polyelectrolyte capsules.
To utilize microgel templates for creating robust capsule walls.
To explore potential applications in microreactors and drug delivery.

Main Methods:

Synthesis of monodisperse, degradable dextran microgels using microfluidics.
Layer-by-layer coating of microgels with platinum nanoparticles and diazoresin.

More Related Videos

High Throughput Single-cell and Multiple-cell Micro-encapsulation

High Throughput Single-cell and Multiple-cell Micro-encapsulation

Published on: June 15, 2012

Fabricating Highly Open Porous Microspheres (HOPMs) via Microfluidic Technology

Fabricating Highly Open Porous Microspheres (HOPMs) via Microfluidic Technology

Published on: May 16, 2022

Related Experiment Videos

Last Updated: Jun 14, 2026

Microfluidic Fabrication of Core-Shell Microcapsules carrying Human Pluripotent Stem Cell Spheroids

Microfluidic Fabrication of Core-Shell Microcapsules carrying Human Pluripotent Stem Cell Spheroids

Published on: October 13, 2021

High Throughput Single-cell and Multiple-cell Micro-encapsulation

High Throughput Single-cell and Multiple-cell Micro-encapsulation

Published on: June 15, 2012

Fabricating Highly Open Porous Microspheres (HOPMs) via Microfluidic Technology

Fabricating Highly Open Porous Microspheres (HOPMs) via Microfluidic Technology

Published on: May 16, 2022

Hydrolytic removal of the sacrificial microgel core to form hollow capsules.

Characterization using scanning electron and confocal microscopy.

Main Results:

Successfully fabricated size-monodisperse "giant" hollow polyelectrolyte capsules.
Achieved stable, rigid capsule walls through covalent cross-linking of polymers and nanoparticles.
Demonstrated successful encapsulation of polystyrene particles within the microcapsules.
Confirmed integrity of the polyelectrolyte membrane after core removal.

Conclusions:

The microfluidic and sacrificial templating approach yields robust hollow capsules.
The "giant" capsules are suitable for encapsulating various materials.
Potential applications as microreactors and advanced drug delivery systems are promising.