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Control of Cell Adhesion using Hydrogel Patterning Techniques for Applications in Traction Force Microscopy
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Enhanced adhesion by gecko-inspired hierarchical fibrillar adhesives

Michael P Murphy1, Seok Kim, Metin Sitti

  • 1Department of Mechanical Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213-3890, USA. mikemurphy@cmu.edu

ACS Applied Materials & Interfaces
|April 2, 2010
PubMed

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Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
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Adhesion

Adhesion occurs when one type of molecule is attracted to a different molecule. Water exhibits adhesive properties in the presence of polar surfaces, such as glass or cellulose in plants. For instance, when water is poured into a glass, the positively charged hydrogen molecules of water are more attracted to the negatively charged oxygen molecules in the silica than to the oxygen in neighboring water molecules.
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