Related Experiment Video
Updated: Jun 14, 2026

07:44
TMT Sample Preparation for Proteomics Facility Submission and Subsequent Data Analysis
Published on: June 8, 2020
ProteomeCommons.org collaborative annotation and project management resource integrated with the Tranche repository
James A Hill1, Bryan E Smith, Panagiotis G Papoulias
1Departments of Biological Chemistry and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA.
Journal of Proteome Research
|April 2, 2010
Summary
ProteomeCommons.org offers a Web 2.0 social networking resource for collaborative data annotation. This project management tool enhances data accuracy and supports distributed research groups.
Area of Science:
- Bioinformatics
- Data Management
- Scientific Collaboration
Background:
- Traditional data repositories lack robust collaborative annotation features.
- Need for high-accuracy, compliant annotation in scientific research.
- Dynamic nature of research requires flexible data management tools.
Purpose of the Study:
- To implement a Web 2.0 social networking resource for collaborative data annotation.
- To provide a project management tool supporting individual and distributed research groups.
- To enhance annotation accuracy and compliance rates for scientific datasets.
Main Methods:
- Integration of Web 2.0 social networking concepts with data repositories.
- Development of a dynamic data model to support research innovation.
- Inclusion of annotation tools within a project management framework.
- Creation of a silver-compliant data resource for the cancer Biomedical Informatics Grid (caBIG).
Main Results:
- ProteomeCommons.org provides a functional resource for collaborative data annotation.
- The system supports annotation throughout the project lifecycle with security and monitoring.
- Facilitates collaboration among distributed investigators working on common datasets.
- A caBIG-compliant resource enhances access to Tranche repository annotations.
Conclusions:
- The implemented resource effectively supports collaborative annotation of scientific datasets.
- The project management integration ensures annotation accuracy and compliance.
- The dynamic data model accommodates the evolving needs of basic research.
- Broader data accessibility is achieved through caBIG integration.
Related Concept Videos
Genome Annotation and Assembly
The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
Proteomics
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...
Protein Complex Assembly
Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types. Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
Many viruses self-assemble into a fully functional unit using the infected host cell to...
Protein Complex Assembly
Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types. Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
Many viruses self-assemble into a fully functional unit using the infected host cell to...
Protein Networks
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Protein Networks
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...

