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All-cause and cardiovascular mortality in treated patients with severe hypertriglyceridaemia: A long-term prospective

H A W Neil1, J Cooper, D J Betteridge

  • 1NIHR School of Primary Care Research, Division Public Health & Primary Health Care, University of Oxford, Old Road, Headington, Oxford OX3 7LF, United Kingdom. andrew.neil@wolfson.ox.ac.uk

Atherosclerosis
|April 2, 2010
PubMed

Insights

Severe hypertriglyceridaemia significantly increases cardiovascular disease mortality, even without diabetes. Management should focus on lowering triglycerides to prevent pancreatitis and reduce overall cardiovascular risk.

Area of Science:

  • Cardiology
  • Endocrinology
  • Public Health

Background:

  • Severe hypertriglyceridaemia (triglycerides >5.0 mmol/l) is a condition characterized by significantly elevated triglyceride levels.
  • This condition is associated with an increased risk of pancreatitis and potentially cardiovascular disease.

Purpose of the Study:

  • To investigate the association between severe hypertriglyceridaemia and all-cause and cardiovascular mortality.
  • To determine if this association persists independently of diabetes and pre-existing coronary heart disease.

Main Methods:

  • A prospective study of 337 patients with severe hypertriglyceridaemia, recruited from 21 UK lipid clinics.
  • Patients were followed for 4353 person-years between 1980 and 2008.
  • Standardised Mortality Ratios (SMR) were calculated by comparing mortality rates to the general population.

Main Results:

  • A significantly elevated SMR for coronary heart disease (CHD) was observed (327), persisting after excluding patients with diabetes (287) or prior CHD (259).
  • The highest SMR for CHD was noted in younger men aged 40-59 (544).
  • Elevated SMRs were also found for stroke (262) and all-cause mortality (164).

Conclusions:

  • Severe hypertriglyceridaemia is linked to substantially increased cardiovascular disease mortality, independent of diabetes.
  • Treatment strategies should prioritize triglyceride reduction to mitigate pancreatitis risk and manage overall cardiovascular risk.
Abstract

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