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Phloridzin: biosynthesis, distribution and physiological relevance in plants
Christian Gosch1, Heidi Halbwirth, Karl Stich
1Vienna University of Technology, Institute of Chemical Engineering, Vienna, Austria.
Phytochemistry
|April 2, 2010
Summary
Phloridzin, a phenolic compound abundant in apples, is a dihydrochalcone with known health benefits. Its biosynthesis involves specific enzymes, though its role in plants remains unclear.
Area of Science:
- Biochemistry
- Plant Science
- Pharmacology
Background:
- Phloridzin is a dihydrochalcone found abundantly in apple trees (Malus sp.).
- Its physiological role in plants is not fully understood, but its effects on human health, particularly diabetes and membrane permeability, are well-documented.
- Phloridzin exhibits species- and tissue-specific distribution within Malus sp.
Purpose of the Study:
- To investigate the biosynthesis of phloridzin.
- To identify the enzymes involved in phloridzin synthesis.
Main Methods:
- Utilized recombinant enzymes and plant protein extracts.
- Investigated NADPH-dependent dehydrogenase, chalcone synthase, and UDP-glucose:phloretin 2'-O-glycosyltransferase activities.
Main Results:
- The study elucidated key enzymatic steps in phloridzin biosynthesis.
- Confirmed the involvement of specific enzymes in the pathway.
Conclusions:
- The biosynthesis of phloridzin has been characterized using biochemical approaches.
- Further research is needed to fully understand the in planta role of phloridzin.
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