Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Lung hyaluronan during development: a quantitative and morphological study.

S J Allen¹, E Gunnar Sedin, A Jonzon

¹Department of Anesthesiology, University of Texas, Houston 77030.

The American Journal of Physiology

|May 1, 1991

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

HEALTH-RELATED QUALITY OF LIFE OF CHILDREN WITH AND WITHOUT SICKLE CELL ANAEMIA AT EDWARD FRANCIS SMALL TEACHING HOSPITAL, THE GAMBIA.

West African journal of medicine·2024

Same author

Assessing the use of minimally invasive self-sampling at home for long-term monitoring of the microbiota within UK families.

Scientific reports·2023

Same author

Perioperative management of patients with a ventricular assist device undergoing non-cardiac surgery.

BJA education·2023

Same author

Ease and comfort of pre-oxygenation with high-flow nasal oxygen cannulae vs. facemask: a randomised controlled trial.

Anaesthesia·2022

Same author

New Method of Reduction of Dislocation of the Hip.

The Southern medical record·2022

Same author

Surface acceleration transmission during drop landings in humans.

Journal of biomechanics·2021

Same journal

Blood coagulation in fish.

The American journal of physiology·2011

Same journal

Renal tubular reabsorption, metabolic utilization and isomeric fractionation of lactic acid in the dog.

The American journal of physiology·2010

Same journal

The inactivation of placental toxin by human serum.

The American journal of physiology·2010

Same journal

Adrenal function following ovariectomy in the rat.

The American journal of physiology·2010

Same journal

Capillary permeability; perfusion of frog and guinea pig hind limbs.

The American journal of physiology·2010

Same journal

Evaluation of protective measures against sunburn.

The American journal of physiology·2010

See all related articles

Lung hyaluronan concentration and distribution change significantly during the perinatal period. Initially high for fetal lung development, it decreases before birth and shifts roles postnatally to fluid balance regulation.

Area of Science:

Developmental Biology
Pulmonology
Biochemistry

Background:

Hyaluronan is crucial for fetal lung development, mediating cell interactions and forming hydrated matrices for cell migration.
Lung hyaluronan matrix contracts before birth, yet continued perinatal lung growth necessitates new hyaluronan synthesis.

Purpose of the Study:

To investigate the dynamic changes in lung hyaluronan concentration and its spatial distribution throughout the perinatal period.

Main Methods:

Quantified hyaluronan concentration in rabbit lungs at multiple time points from late gestation (day -6) to postnatal day 4, including adult controls.
Assessed hyaluronan distribution using staining techniques in lung tissue across the perinatal stages.

Main Results:

Related Experiment Videos

Hyaluronan concentration was highest in early fetal development, decreasing significantly just before birth, and then partially recovering to near-adult levels by postnatal day 4.
Hyaluronan staining diminished in the interalveolar regions during late gestation.
Postnatally, hyaluronan staining increased in the visceral pleura and beneath bronchial epithelium, but not in the interalveolar space.

Conclusions:

Lung hyaluronan's primary role shifts from facilitating lung morphogenesis before birth to regulating interstitial fluid balance in the neonatal period.
These findings highlight the dynamic nature of hyaluronan in the developing and maturing lung.