Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hormonal Regulation01:33

Hormonal Regulation

The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A model of hemodialysis after acute kidney injury in rats.

Intensive care medicine experimental·2023
Same author

Carnosinase Gene-Is It Responsible for Diabetic Nephropathy?: Carnosine as a Protective Factor in Diabetic Nephropathy: Association with a Leucine Repeat of the Carnosinase Gene CNDP1. Diabetes 54: 2320-2327, 2005.

Journal of the American Society of Nephrology : JASN·2023
Same author

Specificities of Meningitis and Meningo-Encephalitis After Kidney Transplantation: A French Retrospective Cohort Study.

Transplant international : official journal of the European Society for Organ Transplantation·2023
Same author

Immediate Impact of Induction Treatment on Postvaccination SARS-CoV-2 Serology in Kidney Transplant Recipients.

Transplantation·2021
Same author

Are script concordance tests suitable for the assessment of undergraduate students? A multicenter comparative study.

La Revue de medecine interne·2020
Same author

Intravesical BCG instillation as a possible cause of acute and chronic kidney injury.

Infectious diseases now·2020
Same journal

Annales francaises d'anesthesie et de reanimation·2020
Same journal

[Multimodal approach to enhance filter lifespan: are all actions equal?].

Annales francaises d'anesthesie et de reanimation·2014
Same journal

[Disparity of French Emergency medical services equipment: disparity of funding allocation or of management quality?].

Annales francaises d'anesthesie et de reanimation·2014
Same journal

[Eligibility to a Maastricht III - type organ donation according to the protocol proposed by the French organ procurement organization (Agence de la biomedicine) among patients in a medico surgical intensive care unit].

Annales francaises d'anesthesie et de reanimation·2014
Same journal

[Enhanced recovery after elective colorectal surgery: reply].

Annales francaises d'anesthesie et de reanimation·2014
Same journal

[Aorto-right atrial fistula as complication of aortic dissection].

Annales francaises d'anesthesie et de reanimation·2014
See all related articles

Related Experiment Video

Updated: Jun 14, 2026

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas
05:31

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas

Published on: January 26, 2024

[Kidney and preeclampsia].

B Moulin1, A Hertig, E Rondeau

  • 1Service de néphrologie, hôpitaux universitaires de Strasbourg, hôpital Civil, 67091 Strasbourg cedex, France. Bruno.Moulin@chru-strasbourg.fr

Annales Francaises D'Anesthesie Et De Reanimation
|April 2, 2010
PubMed
Summary
This summary is machine-generated.

Pregnancy involves significant renal and cardiovascular changes. Preeclampsia (PE) can cause acute kidney injury, often with poor outcomes, but recovery is typical after the acute phase.

More Related Videos

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

Related Experiment Videos

Last Updated: Jun 14, 2026

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas
05:31

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas

Published on: January 26, 2024

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

Area of Science:

  • Obstetrics and Gynecology
  • Nephrology
  • Cardiovascular Physiology

Context:

  • Pregnancy induces substantial physiological adaptations in renal function, including increased renal blood flow and glomerular filtration rate (GFR).
  • Normal pregnancy is characterized by decreased peripheral vascular resistance and a transient drop in blood pressure, counter-regulated by the renin-angiotensin system.
  • Preeclampsia (PE) is a hypertensive disorder of pregnancy presenting with hypertension, proteinuria, and edema, necessitating differential diagnosis with essential hypertension or renal failure.

Purpose:

  • To elucidate the physiological changes in renal function and blood pressure during normal pregnancy.
  • To outline the diagnostic criteria and differential diagnoses for preeclampsia (PE).
  • To describe the causes, clinical presentation, histological features, and prognosis of acute kidney injury in pregnancy, particularly PE-associated acute renal failure and postpartum Hemolytic-Uremic Syndrome (HUS).

Summary:

  • Normal pregnancy features a 50% increase in GFR due to extracellular fluid expansion and sodium retention, alongside a blood pressure decrease mitigated by the renin-angiotensin system.
  • Preeclampsia (PE) is diagnosed by hypertension, proteinuria, and edema; isolated signs warrant investigation for fetal effects. Differential diagnosis includes essential hypertension and renal failure.
  • PE-associated acute renal failure, marked by acute tubular necrosis and endotheliosis, carries a 10% mortality. Postpartum HUS requires prompt diagnosis and treatment.

Impact:

  • Understanding these physiological shifts is crucial for differentiating normal pregnancy adaptations from pathological conditions like PE.
  • Accurate diagnosis and management of PE and its renal complications are vital for maternal and fetal outcomes.
  • Early recognition of acute kidney injury and HUS in pregnancy can improve prognosis and reduce the need for long-term dialysis or mortality.