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Chlorin e6-cholesterol conjugate and its copper complex. Simple synthesis and entrapping in phospholipid vesicles
Irina A Nikolaeva1, Alexander Yu Misharin, Gelii V Ponomarev
1V.N. Orekhovich Institute of Biomedical Chemistry RAMS, Moscow, Russia.
Bioorganic & Medicinal Chemistry Letters
|April 2, 2010
Abstract:
Synthesis of 13'[(cholest-5-en)-3beta-yloxyethoxycarbamoyl]-chlorin e6 starting from methylpheophorbide and 3beta(2-hydroxy)-ethoxycholest-5-ene is presented, as well as the preparation of related copper complex. Both conjugates obtained may be simply incorporated in phosphatidyl choline vesicles.

