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Clinical spectrum of ankylosing spondylitis in Korea

Tae-Jong Kim1, Tae-Hwan Kim

  • 1Department of Rheumatology, The Hospital for Rheumatic Diseases, Hanyang University College of Medicine, 17 Haengdang-Dong, Sungdong-Gu, Seoul 133-792, Republic of Korea.

Joint Bone Spine
|April 2, 2010
PubMed

Insights

Ankylosing spondylitis (AS) in Korea shows higher rates of peripheral arthritis and hip involvement. Female patients experience more uveitis, and juvenile-onset AS (JoAS) is prevalent.

Area of Science:

  • Rheumatology
  • Clinical Medicine
  • Epidemiology

Background:

  • Ankylosing spondylitis (AS) is a chronic inflammatory disease primarily affecting the axial skeleton.
  • Understanding the clinical profile of AS in diverse populations is crucial for effective management.

Purpose of the Study:

  • To delineate the clinical characteristics of ankylosing spondylitis (AS) in the Korean population.
  • To identify unique epidemiological and clinical features of AS in Korea.

Main Methods:

  • A cross-sectional study involving 830 participants (732 men, 98 women) diagnosed with AS.
  • Data collection included extensive questionnaires and clinical evaluations by rheumatologists.
  • Review of previous medical records was performed for all participants.

Main Results:

  • The mean age of onset for AS was 20.9 years.
  • High prevalence of peripheral arthritis (47.1%) and hip joint involvement (73.9%) was observed.
  • Juvenile-onset AS (JoAS) accounted for 28.7% of cases, with higher rates of peripheral arthritis and hip involvement.
  • Uveitis was more frequent in women (40.8%) than men (28.2%).
  • HLA-B27 positivity was associated with earlier onset, more uveitis, and greater hip involvement.

Conclusions:

  • Korean AS patients exhibit a higher prevalence of peripheral arthritis and hip joint involvement compared to other populations.
  • Female patients with AS show a higher incidence of uveitis.
  • Juvenile-onset AS (JoAS) is a significant subtype within the studied Korean cohort.
Abstract

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