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Related Concept Videos

Prevalence and Incidence01:08

Prevalence and Incidence

In statistical epidemiology and health sciences, two essential metrics—prevalence and incidence—are fundamental for understanding disease dynamics within a population. These measures enable public health officials, epidemiologists, and researchers to assess the burden of diseases, allocate resources effectively, and design impactful public health policies and interventions.
Prevalence indicates the proportion of individuals in a population who have a specific disease or health condition at a...
Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Infertility in Males01:23

Infertility in Males

Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

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Isolation, Culture, and Characterization of Prostate Cancer-Associated Fibroblasts
09:43

Isolation, Culture, and Characterization of Prostate Cancer-Associated Fibroblasts

Published on: August 1, 2025

Prostate cancer incidence rates have started to decrease in central Italy.

Emanuele Crocetti1, Stefano Ciatto, Carlotta Buzzoni

  • 1Clinical and Descriptive Epidemiology Unit - ISPO, Via di San Salvi 12, Florence 50135, Italy. e.crocetti@ispo.toscana.it

Journal of Medical Screening
|April 2, 2010
PubMed
Summary
This summary is machine-generated.

Prostate-specific antigen (PSA) screening initially increased prostate cancer incidence globally. Recent data from Italy shows a decline in prostate cancer rates, mirroring trends seen in the US after widespread PSA testing.

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A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance
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A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

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Isolation, Culture, and Characterization of Prostate Cancer-Associated Fibroblasts
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A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance
05:19

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

Published on: November 7, 2025

Area of Science:

  • Oncology
  • Epidemiology
  • Public Health

Background:

  • Widespread prostate-specific antigen (PSA) testing has significantly altered prostate cancer epidemiology worldwide.
  • Increased PSA screening usage has led to documented rises in prostate cancer incidence across Western nations.

Purpose of the Study:

  • To analyze prostate cancer incidence trends in central Italy following the introduction and widespread use of PSA testing.
  • To investigate if Italy exhibits a decline in prostate cancer incidence post-screening increase, similar to observed patterns elsewhere.

Main Methods:

  • Retrospective analysis of prostate cancer incidence data from the Tuscany Cancer Registry.
  • Comparison of incidence rates before and after the peak observed in the early 2000s.

Main Results:

  • Prostate cancer incidence in Tuscany doubled from the early 1990s to 2003.
  • Following this peak, incidence rates in the region have subsequently decreased.
  • This marks the first reported decline in Italian prostate cancer incidence linked to PSA screening.

Conclusions:

  • PSA screening has a demonstrable impact on prostate cancer incidence trends, including eventual declines.
  • The Tuscany Cancer Registry data provides crucial evidence of this phenomenon in Italy.
  • Further research is warranted to understand the long-term implications of PSA screening on prostate cancer outcomes.