Pulmonary meningioma. Immunohistochemical and ultrastructural features

Area of Science:

• Pulmonary Pathology
• Neurosurgical Oncology
• Tumor Histology

Background:

• Meningiomas are typically intracranial tumors. Primary pulmonary meningiomas are exceptionally rare, posing diagnostic challenges.
• Distinguishing primary pulmonary meningiomas from metastatic intracranial meningiomas is crucial for patient management and prognosis.

Observation:

• Two cases of solitary pulmonary tumors exhibited immunohistochemical and ultrastructural features consistent with meningothelial meningiomas.
• Clinical and radiological evaluations, including brain CT scans and neuropathological investigations, were negative for intracranial meningiomas.
• Specific neuroendocrine markers were negative, and electron microscopy did not reveal neurosecretory granules.

Findings:

• The presented cases represent primary pulmonary meningiomas, confirmed by characteristic histological and ultrastructural findings.
• The absence of intracranial or metastatic disease supports a primary origin within the lung.
• Exclusion of neuroendocrine differentiation further refines the diagnosis of this rare pulmonary neoplasm.

Implications:

• This study expands the understanding of rare pulmonary neoplasms and their differential diagnoses.
• Accurate diagnosis of primary pulmonary meningioma is essential for appropriate clinical and therapeutic strategies.
• Further research into the pathogenesis and behavior of primary pulmonary meningiomas is warranted.