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Extramedullary hematopoiesis in the prostate.
1Veterans Administration, Durham, North Carolina.
The American Journal of Surgical Pathology
|May 1, 1991
Summary
This case study details myelofibrosis with extramedullary hematopoiesis in the prostate. This rare finding in the prostate gland requires consideration in diagnosing stromal lesions.
Area of Science:
- Hematology
- Pathology
- Urology
Background:
- Myelofibrosis is a chronic bone marrow disorder.
- Extramedullary hematopoiesis (EMH) is the formation of blood cells outside the bone marrow.
- Prostate involvement with EMH is exceptionally rare.
Observation:
- A 75-year-old male with an 8-year history of myelofibrosis presented with bladder outlet obstruction.
- Microscopic examination of prostatic tissue revealed atypical megakaryocytes, immature granulocytes, and normoblasts in the stroma.
- Prostatic glandular epithelium remained uninvolved.
Findings:
- Histopathological analysis confirmed extramedullary hematopoiesis within the prostate.
- Immunohistochemistry (hemoglobin and chloroacetate esterase stains) aided in diagnosis and assessing the extent of EMH.
- The findings highlight a rare manifestation of myelofibrosis.
Implications:
- Extramedullary hematopoiesis in the prostate should be considered in the differential diagnosis of prostatic stromal lesions.
- This case expands the understanding of the potential sites for EMH in myelofibrosis.
- Accurate diagnosis is crucial for appropriate patient management.