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Published on: March 11, 2016
Early and sustained systemic and renal hemodynamic effects of intravenous radiocontrast
Takao Saotome1, Christoph Langenberg, Li Wan
1Howard Florey Institute, University of Melbourne, Parkville, Vic., Australia.
Background And Aims:
To measure the extended renal hemodynamic changes induced by intravenous radiocontrast.
Methods:
Cross-ewes were studied in a randomized cross-over study. Intravenous saline or radiocontrast were administered, and continuous measurement of cardiac output and renal blood flow (RBF) was performed with flow probes.
Results:
Radiocontrast induced early but transient increases in cardiac output with vasodilatation, followed by return to baseline values within 2 h. There was an initial decline in RBF (-5.2 +/- 4.5 vs. 2.1 +/- 5.3%; p < 0.0001) and decreased renal vascular conductance (-4.0 +/- 7.2 vs. 3.3 +/- 7.1%, p < 0.0001; vasoconstriction). This renal vasoconstriction resolved within 2 h and was followed by sustained (72 h) renal vasodilatation with higher RBF (270 +/- 13 vs. 236 +/- 11 ml/min; p < 0.0001).
Conclusions:
Radiocontrast induces short renal vasoconstriction followed by sustained vasodilatation and increased RBF. Short-term studies are not representative of the overall sustained renal hemodynamic effects of radiocontrast.
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