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Mucinous cystadenomas in liver: management and origin
D Erdogan1, J Kloek, W H Lamers
1Department of Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Digestive Surgery
|April 2, 2010
Summary
Ovarian stroma (OS) presence is key for diagnosing mucinous liver cystadenomas. This finding suggests a shared embryonic origin between these rare liver tumors and OS from early fetal gonad development.
Area of Science:
- Hepatobiliary Surgery
- Surgical Pathology
- Embryology
Background:
- Mucinous cystadenomas are rare hepatic neoplasms.
- Management strategies for suspected liver cystadenomas/cystadenocarcinomas require assessment.
- Investigating the embryonic origin of ovarian stroma (OS) in these tumors is crucial.
Purpose of the Study:
- To evaluate the management of patients with suspected mucinous liver cystadenoma or cystadenocarcinoma.
- To examine the presence and origin of ovarian stroma (OS) in mucinous liver cystadenomas.
Main Methods:
- Retrospective review of 15 surgically treated patients (1994-2009) with hepatic tumors.
- Pathology specimen analysis for OS presence in resected mucinous liver cystadenomas/cystadenocarcinomas.
- Embryonic examination of peritoneal epithelium and gonad positioning relative to abdominal organs.
Main Results:
- 15 patients diagnosed with mucinous liver tumors (12 cystadenomas, 3 cystadenocarcinomas).
- Ovarian stroma (OS) was identified in all female patients.
- Male patients were reclassified as intraductal papillary mucinous neoplasms (IPMNs); embryonic gonads showed activated peritoneal epithelium.
Conclusions:
- Ovarian stroma (OS) presence is a prerequisite for diagnosing mucinous liver cystadenoma.
- The findings support a common embryonic origin from gonad-associated epithelial cells for cystadenomas and OS.
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