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Published on: April 13, 2010
Asthmatics without rhinitis have more fixed airway obstruction than those with concurrent rhinitis
An-Soo Jang1, Jong-Sook Park, June-Hyuk Lee
1Asthma and Allergy Research Group, Division of Allergy and Respiratory Diseases, Soonchunhyang University, Bucheon Hospital, Bucheon, Korea.
Allergy, Asthma & Immunology Research
|April 2, 2010
Summary
Asthma patients with allergic rhinitis (AR) show higher rates of atopy and aspirin intolerance. These patients also exhibit poorer response to anti-inflammatory drugs, indicating more fixed airway obstruction.
Area of Science:
- Pulmonology
- Allergy and Immunology
Background:
- Rhinitis and asthma frequently coexist, with allergic rhinitis (AR) potentially impacting asthma's clinical progression.
- Understanding the interplay between asthma and AR is crucial for effective patient management.
Purpose of the Study:
- To compare clinical parameters and therapeutic responses in patients with asthma versus those with asthma and AR.
- To identify differences in airway obstruction and treatment outcomes between the two groups.
Main Methods:
- Recruited 485 asthma patients and 428 asthmatics with AR (age <50, smoking <10 pack-years).
- Compared FEV1, FEV1/FVC, atopy, IgE, HRCT emphysema, and aspirin intolerance.
- Assessed fixed airway obstruction post-1-year anti-asthmatic drug treatment.
Main Results:
- 46.8% of asthmatics had AR. No significant differences in IgE, BMI, PC20, sputum eosinophils, or emphysema.
- Asthmatics with AR had higher atopy and aspirin intolerance prevalence.
- Asthma patients without AR showed lower FEV1/FVC and higher rates of fixed airway obstruction after treatment.
Conclusions:
- Asthma patients with AR present with more atopy and aspirin intolerance.
- Concurrent rhinitis in asthma patients is associated with poorer response to anti-inflammatory drugs and increased fixed airway obstruction.
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