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Polypropylene CD-organic light-emitting diode biosensing platform.

Srikanth Vengasandra1, Yuankun Cai, David Grewell

  • 1Department of Agricultural & Biosystems Engineering, Iowa State University, Ames, IA 50011, USA.

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This study presents a compact lab-on-CD platform for simultaneous sensing of glucose, lactate, ethanol, and dissolved oxygen using photoluminescence. The device utilizes microfluidic features and organic light-emitting diodes for sensitive, field-deployable multi-analyte monitoring.

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Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Microfluidics

Background:

  • Existing multi-analyte sensing platforms can be complex and costly.
  • There is a need for portable and integrated devices for point-of-care diagnostics.

Purpose of the Study:

  • To develop a compact, lab-on-CD platform for simultaneous photoluminescence (PL)-based sensing of multiple bioanalytes.
  • To demonstrate the feasibility of using microfluidic features on foamed polypropylene (PP) with organic light-emitting diode (OLED) pixels and photodetectors (PDs) for sensing.

Main Methods:

  • Microfluidic features were fabricated on foamed PP using ultrasonic micro-embossing.
  • Sub-micron thick OLED pixels and compact PD arrays were integrated for PL excitation and detection.
  • Simultaneous monitoring of glucose, lactate, ethanol, and dissolved oxygen (DO) was achieved using an oxygen-sensitive dye and measuring PL decay time.

Main Results:

  • The platform enabled sensitive and accurate determination of individual analyte concentrations and mixtures.
  • Calibration curves were established for each analyte on separate CD segments.
  • The system successfully monitored analyte concentrations by measuring DO consumption during oxidation reactions.

Conclusions:

  • The developed OLED-bio-CD-PD platform offers a sensitive, accurate, and potentially field-deployable solution for simultaneous multi-analyte sensing.
  • This integrated system demonstrates the utility of lab-on-CD technology for complex bioanalytical tasks.