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In vivo Characterization of Endocrine Disrupting Chemical Effects via Thyroid Hormone Action Indicator Mouse
Published on: October 6, 2023
[Organ manifestations of hyperthyroidism]
R Hörmann1, P M Schumm-Draeger
1Klinik für Allgemeine Innere Medizin, Endokrinologie und Gastroenterologie, Klinikum Lüdenscheid, Paulmannshöher Strasse 14, 58515, Lüdenscheid, Deutschland. rudolf.hoermann@gmail.com
Insights
Early diagnosis and treatment of hyperthyroidism are crucial, especially given its cardiovascular risks and subclinical onset. Recognizing diverse symptoms is key to managing this prevalent thyroid disorder.
Area of Science:
- Endocrinology
- Cardiovascular Medicine
- Pathophysiology
Context:
- Hyperthyroidism often presents with subtle symptoms, leading to delayed diagnosis and treatment.
- Cardiovascular complications are the most serious and prevalent issue in hyperthyroid patients, increasing mortality.
- Subclinical hyperthyroidism necessitates early intervention to prevent adverse outcomes.
Purpose:
- To review the multifaceted impact of thyroid disorders on various organ systems.
- To highlight the cardiovascular implications and increased mortality associated with hyperthyroidism.
- To emphasize the importance of early diagnosis and treatment, even in subclinical stages.
Summary:
- Thyroid hormones significantly influence multiple organs, and symptoms across systems should prompt suspicion of thyroid disease.
- Cardiovascular disease is a major concern in hyperthyroidism, linked to higher mortality rates.
- Research into selective thyroid hormone analogues offers future therapeutic potential.
Impact:
- Increased awareness of hyperthyroidism's systemic effects and cardiovascular risks.
- Promotes timely medical consultation and intervention for hyperthyroid patients.
- Facilitates the development of targeted therapies for thyroid disorders.
Abstract:
Patients with hyperthyroidism tend to feel well and procrastinate the visit to the doctor and hence diagnosis of the disease. Among a whole variety of more or less distinct symptoms affecting many organs, cardiovascular disease is most prevalent and serious, because it relates to an increase in mortality of patients with hyperthyroidism. Recent epidemiological studies have clearly demonstrated that the disease already begins with the subclinical states of hyperthyroidism and, as a consequence, treatment should also be commenced early on. Novel insights into the mechanisms and actions of thyroid hormones at the pathophysiological level offer a potential for the development and future therapeutic use of selective hormone analogues. Despite the high frequency and importance of thyroid disorders, awareness appears to be decreasing and over-dosage of thyroid hormones in benign thyroid conditions is frequent. This review should emphasize that the thyroid gland affects the structure and function of a multitude of organs and, on the other hand, many symptoms and complaints, related to various organ systems, should raise suspicion of thyroid disease.
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Hyperthyroidism I: Introduction
Hyperthyroidism II: Pathophysiology
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Graves Disease II: Pathophysiology
Hypothyroidism II: Pathophysiology
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