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Phospholipid Polymer Biointerfaces for Lab-on-a-Chip Devices.

Yan Xu¹, Madoka Takai, Kazuhiko Ishihara

¹Department of Materials Engineering, School of Engineering, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan, xuyan@icl.t.u-tokyo.ac.jp.

Annals of Biomedical Engineering

|April 2, 2010

Summary

Functional phospholipid polymer biointerfaces made from 2-methacryloyloxyethyl phosphorylcholine (MPC) polymers offer cell-membrane-like surfaces. These advanced biointerfaces effectively suppress biofouling and control microfluidic flow for lab-on-a-chip applications.

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Area of Science:

Biomaterials Science
Surface Chemistry
Microfluidics

Background:

Phospholipid polymers, specifically 2-methacryloyloxyethyl phosphorylcholine (MPC) polymers, mimic cell membranes.
MPC polymers provide biointerfaces that reduce protein adsorption and biological responses.
Lab-on-a-chip devices require advanced biointerfaces for effective functionality.

Purpose of the Study:

To review recent advancements in functional MPC polymer biointerfaces for lab-on-a-chip devices.
To highlight the design and synthesis of MPC polymers with tailored functionalities.
To demonstrate the application of these biointerfaces in microfluidic systems and biomedical applications.

Main Methods:

Design and synthesis of MPC polymers incorporating functional units (charge, active ester).

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Modification of polymers with silane or hydrophobic moieties for stable interface construction.

Characterization of interfacial properties (chemistry, physics, biology).

Main Results:

Successfully created stable MPC polymer interfaces on diverse substrates (glass, PDMS, etc.).
Achieved suppression of nonspecific bioadsorption and controlled microfluidic flow.
Demonstrated successful chip-based biomedical applications, including immunoassays and DNA separation.

Conclusions:

Functional MPC polymer biointerfaces are highly promising for lab-on-a-chip devices.
These interfaces offer significant advantages in suppressing biofouling and enabling precise fluid control.
The development of these phospholipid polymer interfaces opens new avenues for biomedical applications on a chip.