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Related Experiment Video

Updated: Jun 14, 2026

Use of a Central Venous Line for Fluids, Drugs and Nutrient Administration in a Mouse Model of Critical Illness

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[Endocrine regulation in critically ill patients].

¹Interdisziplinäres Notfallzentrum mit Rettungsstelle, Helios-Klinikum Berlin-Buch. christian.wrede@helios-kliniken.de

Deutsche Medizinische Wochenschrift (1946)

|April 2, 2010

Summary

Critically ill patients often experience hormonal imbalances. While intensive glucose control and low-dose hydrocortisone showed initial promise, later studies yielded mixed results, prompting a review of endocrine regulation in critical care.

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Last Updated: Jun 14, 2026

Use of a Central Venous Line for Fluids, Drugs and Nutrient Administration in a Mouse Model of Critical Illness

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Published on: May 2, 2017

Improving IV Insulin Administration in a Community Hospital

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Published on: June 11, 2012

Area of Science:

Endocrinology
Critical Care Medicine

Context:

Hormonal regulation disturbances are common in critically ill patients.
Intensive blood glucose control and low-dose hydrocortisone therapy for sepsis gained attention for potential mortality benefits.

Purpose:

To review endocrine dysregulation in critically ill patients.
To discuss the evolving understanding of hormonal interventions in critical care.

Summary:

Initial positive findings for intensive glucose control and hydrocortisone therapy in critical care were not consistently replicated in large multi-center studies.
This review examines these interventions and other endocrine disturbances in critically ill patients.

Impact:

Highlights the need for cautious interpretation of early clinical trial results in critical care.
Informs clinical practice and guideline development regarding endocrine management in critically ill patients.