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Updated: Jun 14, 2026

Interlinked Macroporous 3D Scaffolds from Microgel Rods

Interlinked Macroporous 3D Scaffolds from Microgel Rods

Published on: June 16, 2022

Interface-directed self-assembly of cell-laden microgels.

Behnam Zamanian¹, Mahdokht Masaeli, Jason W Nichol

¹Center for Biomedical Engineering Department of Medicine Brigham and Women's Hospital Harvard Medical School 65 Landsdowne Street, Cambridge, MA 02139, USA.

Small (Weinheim an Der Bergstrasse, Germany)

|April 2, 2010

Summary

Researchers developed a rapid method to create centimeter-scale, cell-laden hydrogels for tissue engineering. This technique uses shape-controlled microgels and a liquid-air interface for precise spatial control of cell distribution in engineered tissues.

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Area of Science:

Biomaterials Science
Tissue Engineering
Microfluidics

Background:

Cell-laden hydrogels are promising for engineered tissues.
Current methods lack control over micrometer-scale features.
Fabricating biologically relevant structures remains a challenge.

Purpose of the Study:

To develop a rapid method for fabricating centimeter-scale, cell-laden hydrogels.
To achieve controlled micrometer-scale features in engineered tissues.
To enable precise spatial control over cell distribution.

Main Methods:

Assembly of shape-controlled microgels at a liquid-air interface.
Induction of microgel aggregation and crosslinking into macroscale structures.
Hierarchical assembly of complex multigel building blocks for cocultured tissues.

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Published on: August 7, 2016

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Last Updated: Jun 14, 2026

Interlinked Macroporous 3D Scaffolds from Microgel Rods

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Published on: June 16, 2022

Microfluidic Synthesis of Microgel Building Blocks for Microporous Annealed Particle Scaffold

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Layered Alginate Constructs: A Platform for Co-culture of Heterogeneous Cell Populations

Layered Alginate Constructs: A Platform for Co-culture of Heterogeneous Cell Populations

Published on: August 7, 2016

Main Results:

Demonstrated rapid fabrication of centimeter-scale, cell-laden hydrogel sheets.
Achieved tightly packed, ordered microgel units in hydrogel assemblies.
Showcased precise spatial control over cell distribution in cocultured tissue-like structures.

Conclusions:

Forces at air-liquid interfaces can drive self-assembly of tissue constructs.
This method enables the creation of spatially controllable, cocultured tissue-like structures.
Offers a novel approach for advanced tissue engineering applications.