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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
Drug Delivery: Overview01:16

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the gastrointestinal...
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Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...

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Manufacture and Drug Delivery Applications of Silk Nanoparticles
09:03

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

Smart particles for noble drug delivery system.

Cheolyoung Park1, Jihoon Kim, Seunghyun Jang

  • 1Department of Chemistry, Chosun University, Gwangju 501-759, Korea.

Journal of Nanoscience and Nanotechnology
|April 3, 2010
PubMed
Summary

Researchers developed optically encoded smart particles for drug delivery using porous silicon dioxide. These particles show optical changes correlating with drug release, offering a new method for monitoring therapeutic delivery.

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Smart drug delivery systems require precise monitoring of drug release.
  • Optically encoded materials offer a non-invasive method for tracking therapeutic processes.
  • Porous silicon (PSi) is a versatile material for fabricating functional nanostructures.

Purpose of the Study:

  • To create optically encoded smart particles for drug delivery.
  • To investigate the correlation between drug release and optical properties.
  • To demonstrate the potential of these particles for real-time monitoring.

Main Methods:

  • Fabrication of Distributed Bragg reflector (DBR) porous silicon (PSi) using a pseudo-square wave current.
  • Conversion of PSi to porous silicon dioxide (PSD) via thermal oxidation.
  • Derivatization of DBR PSD with 20(S)-Camptothecin (CPT) and particle fracturing.
  • Optical characterization using reflectance spectrometry and UV-Vis spectroscopy.

Main Results:

  • DBR PSD smart particles displayed a distinct photonic band gap.
  • Optical properties were maintained in aqueous solutions.
  • Drug release correlated with an increase in peak intensity and a blue shift in the reflection peak.
  • The blue shift indicated a decrease in the refractive index of the PSD particles during drug release.

Conclusions:

  • Optically encoded DBR PSD smart particles are effective for drug delivery.
  • The observed optical changes provide real-time monitoring of drug release.
  • This technology offers a promising platform for advanced drug delivery systems.