[The relationship between the abnormal behavior and serum C-reactive protein in children with obstructive sleep

Yan Wang1, Yanzhong Li, Xin Wang

  • 1Department of Otorhinolaryngology, Qilu Hospital of Shandong University, the Key Laboratory of Otorhinolaryngology of Health Ministry, Jinan, 250000, China.

Insights

Children with obstructive sleep apnea-hypopnea syndrome (OSAHS) and habitual snoring exhibit more behavioral issues. Elevated C-reactive protein levels in these children correlate with abnormal behavior, suggesting a link to inflammation.

Area of Science:

  • Pediatric Sleep Medicine
  • Child Psychology
  • Biomarkers of Inflammation

Background:

  • Obstructive sleep apnea-hypopnea syndrome (OSAHS) is increasingly recognized as a condition impacting children's health beyond respiratory symptoms.
  • Behavioral problems are frequently observed in children with sleep-disordered breathing, but the underlying mechanisms require further elucidation.

Purpose of the Study:

  • To investigate the pathogenesis of abnormal behavior in children diagnosed with OSAHS.
  • To explore the relationship between C-reactive protein (CRP) levels and behavioral issues in children with OSAHS and habitual snoring.

Main Methods:

  • A comparative study involving 40 children with OSAHS, 30 with habitual snoring, and 40 healthy controls.
  • Overnight polysomnography was conducted to diagnose OSAHS and habitual snoring.
  • Behavioral problems and serum C-reactive protein levels were measured in all participants.

Main Results:

  • Children with OSAHS and habitual snoring showed significantly higher rates of abnormal behavior compared to healthy controls.
  • Serum C-reactive protein levels were significantly elevated in children with OSAHS and habitual snoring compared to healthy controls.
  • Higher CRP levels were associated with abnormal behavior in both OSAHS and habitual snoring groups.

Conclusions:

  • OSAHS and habitual snoring are associated with increased behavioral problems in children.
  • Elevated C-reactive protein levels in children with OSAHS and habitual snoring suggest an inflammatory component.
  • CRP levels correlate with the presence and severity of abnormal behavior in these pediatric populations.
Abstract

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