[The relationship between the abnormal behavior and serum C-reactive protein in children with obstructive sleep
Yan Wang1, Yanzhong Li, Xin Wang
1Department of Otorhinolaryngology, Qilu Hospital of Shandong University, the Key Laboratory of Otorhinolaryngology of Health Ministry, Jinan, 250000, China.
Insights
Children with obstructive sleep apnea-hypopnea syndrome (OSAHS) and habitual snoring exhibit more behavioral issues. Elevated C-reactive protein levels in these children correlate with abnormal behavior, suggesting a link to inflammation.
Area of Science:
- Pediatric Sleep Medicine
- Child Psychology
- Biomarkers of Inflammation
Background:
- Obstructive sleep apnea-hypopnea syndrome (OSAHS) is increasingly recognized as a condition impacting children's health beyond respiratory symptoms.
- Behavioral problems are frequently observed in children with sleep-disordered breathing, but the underlying mechanisms require further elucidation.
Purpose of the Study:
- To investigate the pathogenesis of abnormal behavior in children diagnosed with OSAHS.
- To explore the relationship between C-reactive protein (CRP) levels and behavioral issues in children with OSAHS and habitual snoring.
Main Methods:
- A comparative study involving 40 children with OSAHS, 30 with habitual snoring, and 40 healthy controls.
- Overnight polysomnography was conducted to diagnose OSAHS and habitual snoring.
- Behavioral problems and serum C-reactive protein levels were measured in all participants.
Main Results:
- Children with OSAHS and habitual snoring showed significantly higher rates of abnormal behavior compared to healthy controls.
- Serum C-reactive protein levels were significantly elevated in children with OSAHS and habitual snoring compared to healthy controls.
- Higher CRP levels were associated with abnormal behavior in both OSAHS and habitual snoring groups.
Conclusions:
- OSAHS and habitual snoring are associated with increased behavioral problems in children.
- Elevated C-reactive protein levels in children with OSAHS and habitual snoring suggest an inflammatory component.
- CRP levels correlate with the presence and severity of abnormal behavior in these pediatric populations.
Objective:
To explore the pathogenesis of abnormal behavior in children with obstructive sleep apnea-hypopnea syndrome (OSAHS).
Method:
The behavioral problems and C-reactive protein were measured in 40 children with OSAHS and 30 children with habitual snoring who underwent overnight Polysomnography, 40 cases of healthy children for the control group.
Result:
The ratio of abnormal behavior in OSAHS and habitual snoring children was significantly higher than that of the healthy control group, while no significant difference between the two groups. The content of C-reactive protein in OSAHS children (4.24 mg/L) was significantly higher than habitual snoring (2.76 mg/L) and healthy control group (1.27 mg/L); in habitual snoring children C-reactive protein was higher than in healthy control group. The content of serum C-reactive protein in OSAHS children accompanied by abnormal behavior (4.63 mg/L) was significantly higher than that without abnormal behavior (3.23 mg/L). The content of serum C-reactive protein content in habitual snoring children accompanied by abnormal behavior (3.63 mg/L) was significantly higher than that without abnormal behavior (1.76 mg/L).
Conclusion:
OSAHS and habitual snoring children have more behavior problems. C-reactive protein levels are higher in children with OSAHS and habitual snoring, and the levels of C-reactive protein are related to the abnormal behavior in these children.
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