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Published on: September 22, 2023
[Expression of toll-like receptors signaling pathway in chronic rhinosinusitis with nasal polyps]
Xin Wang1, Chunyuan Zhao, Ming Liu
1Department of Otorhinolaryngology Head and Neck Surgery, Second Hospital Affiliated to Harbin Medical Universitry, Harbin,150086, China.
Objective:
To investigate the expression of Toll-like receptors (TLRs) signaling pathway in chronic rhinosinusitis (CRS) with nasal polyps.
Method:
Gene microarray analysis was used to detect the expression of TLRs signaling pathway in CRS with nasal polyps.
Result:
Of 19 differentially expressed (two fold changes), 4 genes were upregulated and 15 genes were downregulated.
Conclusion:
The differentially expressed genes in TLRs signaling pathway may exert its effect in the pathogenesis of CRS. In addition, the roles of TLR9 and its agonists need further study.
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Chronic Pharyngitis
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...

