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[Expression of RAGE in laryngeal squamous cell carcinoma and clinical significance]
Huiping Zhang1, Rong Zhang, Hanjing Shangguan
1Department of Otolaryngology Head and Neck Surgery, First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, Chin.
Objective:
To study the expression and clinical significance of receptor for advanced glycation end products (RAGE) in laryngeal squamous cell carcinoma (LSCC).
Method:
immunohistochemical staining was used to detect the expressions of RAGE protein and semiquantitative method of reverse transcriptase polymerase chain reaction (RT-PCR) was used to analyze the expression level of RAGE mRNA in LSCC tissues and laryngeal normal tissues of 37 cases, respectively.
Result:
The mRNA and protein expression of RAGE was significantly higher in LSCC than that in normal laryngeal tissues (P < 0.05), correlated with differentiation (P < 0.01), but not with tumor stage and location (P > 0.05).
Conclusion:
The expression levels of RAGE were significantly higher in LSCC than these in laryngeal normal tissues, RAGE is involved in differentiation of LSCC.
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