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Cell-Lineage Guided Mass Spectrometry Proteomics in the Developing (Frog) Embryo
Published on: April 21, 2022
LEAPdb: a database for the late embryogenesis abundant proteins
Gilles Hunault1, Emmanuel Jaspard
1Université d'Angers, Laboratoire d'Hémodynamique, Interaction Fibrose et Invasivité tumorale hépatique, UPRES 3859, IFR 132, Université d'Angers, F- 49045 Angers, France.
BMC Genomics
|April 3, 2010
Summary
The Late Embryogenesis Abundant Proteins database (LEAPdb) organizes information on LEAP proteins, aiding research into their functions and structure-function relationships. This resource facilitates the study of LEAP proteins involved in plant abiotic stress tolerance.
Area of Science:
- Biochemistry
- Bioinformatics
- Plant Science
Background:
- Late Embryogenesis Abundant Proteins (LEAP) are crucial for plant abiotic stress tolerance.
- Current classification and molecular functions of LEAP proteins lack consensus.
- Limited 3-D structures hinder the analysis of LEAP structure-function relationships.
Purpose of the Study:
- To develop a comprehensive, user-friendly database for LEAP proteins.
- To facilitate the organization, classification, and analysis of LEAP data.
- To support research into LEAP structure-function relationships.
Main Methods:
- Compilation and curation of LEAP protein data from various organisms.
- Development of a web-based database (LEAPdb) with browse and search functionalities.
- Integration of data from PFAM, Conserved Domain, and InterPro databases for subfamily classification.
Main Results:
- LEAPdb houses 769 curated, full-length LEAP sequences from 196 organisms.
- The database categorizes LEAP proteins into 8 subfamilies.
- Features include sequence similarity search, downloadable data, and user submission capabilities.
Conclusions:
- LEAPdb provides a valuable, centralized resource for LEAP protein research.
- The database supports computational analysis of LEAP structure-function relationships.
- LEAPdb is publicly accessible for scientific community use.
