Related Experiment Video
Updated: Jun 14, 2026
14:39
Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
Published on: November 4, 2010
Asthma: Chronopharmacotherapy and the molecular clock
Naoto Burioka1, Yasushi Fukuoka, Satoru Koyanagi
1Tottori University, Yonago, Japan. burioka@grape.med.tottori-u.ac.jp
Advanced Drug Delivery Reviews
|April 3, 2010
Summary
Asthma symptoms worsen in the early morning, indicating chronotherapy
Area of Science:
- Pulmonary Medicine
- Pharmacology
- Chronobiology
Background:
- Bronchial asthma involves chronic airway inflammation and reversible airflow limitation.
- Asthma symptoms and pulmonary function often worsen in the early morning hours.
- This diurnal variation suggests the potential benefit of chronopharmacotherapy for asthma management.
Purpose of the Study:
- To review the application of chronotherapy in managing bronchial asthma.
- To explore asthma medications developed based on chronopharmacology principles.
- To provide a molecular biological explanation for how asthma medications affect clock genes.
Main Methods:
- Review of existing literature on asthma chronotherapy.
- Analysis of asthma medications designed for chronotherapeutic use.
- Examination of molecular mechanisms linking asthma drugs to circadian clock genes.
Main Results:
- Several asthma medications have been developed utilizing chronopharmacology.
- Once-nightly administration of asthma medications aims to prevent nocturnal symptoms and inflammation.
- Inhaled glucocorticosteroid ciclesonide offers once-daily dosing, enhancing patient compliance.
Conclusions:
- Chronotherapy has demonstrated effectiveness in asthma management, particularly for nocturnal asthma.
- Timing medication administration can optimize asthma control and improve patient outcomes.
- Understanding the influence of medications on clock genes offers insights into asthma's circadian aspects.
Related Concept Videos
01:20Asthma: Pathogenesis and Management
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
01:30Asthma-IV: Diagnostic and Management
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
01:24Antiasthma Drugs: Methylxanthines
Theophylline, a member of the methylxanthine class of bronchodilators, has long been used in asthma management. While its exact mechanism of action is not fully understood, it is believed to have multiple effects on various cellular processes.
Theophylline is thought to inhibit phosphodiesterase enzymes, increasing intracellular levels of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). This rise in cAMP and cGMP concentrations stimulates cardiac function,...
Theophylline is thought to inhibit phosphodiesterase enzymes, increasing intracellular levels of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). This rise in cAMP and cGMP concentrations stimulates cardiac function,...
01:28Asthma I: Introduction
Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
01:15Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
01:25Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...