Related Experiment Video

Updated: Jun 14, 2026

Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography
09:34

Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography

Published on: February 17, 2022

Novel agents in development for peripheral T-cell lymphoma

Owen A O'Connor1

  • 1New York University Cancer Institute, NYU Langone Medical Center, New York, NY, USA. O'Connor@nyumc.org

Seminars in Hematology
|April 3, 2010
PubMed

Insights

Peripheral T-cell lymphoma (PTCL) has unmet needs, but new treatments are emerging. Combining T-cell targeted agents may offer better therapies than current regimens for relapsed or refractory PTCL.

Area of Science:

  • Oncology
  • Hematology
  • Pharmacology

Background:

  • Peripheral T-cell lymphoma (PTCL) represents a significant unmet therapeutic need.
  • Current treatment options for relapsed or refractory PTCL are limited, with a lack of drugs targeting novel disease biology.

Purpose of the Study:

  • To review emerging therapeutic agents for peripheral T-cell lymphoma (PTCL).
  • To explore the potential of novel drug combinations for PTCL treatment.

Main Methods:

  • Literature review of current and investigational drugs for PTCL.
  • Analysis of T-cell centric agents and their mechanisms of action.

Main Results:

  • A range of drugs are in development for PTCL, including pralatrexate, romidepsin, bortezomib, lenalidomide, forodesine, gemcitabine, and BH3-only mimetics.
  • Combinations of T-cell targeted agents show promise for replacing ineffective CHOP-based regimens.

Conclusions:

  • Novel therapeutic platforms combining T-cell centric agents are needed for PTCL.
  • Further research into drug combinations may lead to improved outcomes for PTCL patients.

More Related Videos

Flow Cytometry-based Assay for the Monitoring of NK Cell Functions08:17

Flow Cytometry-based Assay for the Monitoring of NK Cell Functions

Published on: October 30, 2016

Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...