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Related Concept Videos

Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
Facilitated Diffusion01:16

Facilitated Diffusion

The plasma membrane, a critical structure in cellular biology, houses an array of transporters, or carrier proteins, interspersed within its lipid bilayer. These proteins play a crucial role in solute transport through facilitated diffusion, a form of passive diffusion that uses transporters to move the molecules across the membrane.
In this process, substrates such as organic compounds and ions interact with a transporter on one side, triggering conformational changes in proteins that enable...
Continuing Care01:25

Continuing Care

Continuing care describes the variety of health, personal, and social services provided over a prolonged period. The need for continuing care is increasing because people are living longer. Many people do not have families or others to care for them. Continuing care is mainly for patients who are disabled, functionally dependent, or suffering from a terminal disease. It is available within institutional settings or in homes. Examples include nursing centers or facilities, assisted living,...
Cohesion01:07

Cohesion

Cohesion is the attraction between molecules of the same type, such as water molecules. Water molecules have an overall neutral charge but are polar molecule. An oxygen atom in one water molecule has a partial negative charge that can bind to a hydrogen atom with a partial positive charge in a second water molecule, forming a hydrogen bond. Each water molecule can form up to four hydrogen bonds with other water molecules. Hydrogen bonds are responsible for water's cohesive nature.
On a surface,...

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Related Experiment Video

Updated: Jun 14, 2026

Group Synchronization During Collaborative Drawing Using Functional Near-Infrared Spectroscopy
07:53

Group Synchronization During Collaborative Drawing Using Functional Near-Infrared Spectroscopy

Published on: August 5, 2022

Status of ongoing collaborative efforts.

Julie M Vose1

  • 1Division of Hematology/Oncology, University of Nebraska Medical Center, Omaha, NE, USA. jmvose@unmc.edu

Seminars in Hematology
|April 3, 2010
PubMed
Summary
This summary is machine-generated.

The T-Cell Project enhances understanding of rare T-cell lymphomas (TCLs) by pooling global data. This study analyzes treatment responses and survival outcomes for peripheral T-cell lymphoma (PTCL) and natural killer (NK)/T-cell lymphoma patients.

More Related Videos

Operation of the Collaborative Composite Manufacturing (CCM) System
10:09

Operation of the Collaborative Composite Manufacturing (CCM) System

Published on: October 1, 2019

Related Experiment Videos

Last Updated: Jun 14, 2026

Group Synchronization During Collaborative Drawing Using Functional Near-Infrared Spectroscopy
07:53

Group Synchronization During Collaborative Drawing Using Functional Near-Infrared Spectroscopy

Published on: August 5, 2022

Operation of the Collaborative Composite Manufacturing (CCM) System
10:09

Operation of the Collaborative Composite Manufacturing (CCM) System

Published on: October 1, 2019

Area of Science:

  • Hematology
  • Oncology
  • Clinical Research

Background:

  • T-cell lymphomas (TCLs) are rare non-Hodgkin lymphomas (NHLs), leading to limited understanding.
  • Uncommon subtypes of TCLs require further investigation for improved patient outcomes.

Purpose of the Study:

  • To improve the understanding of both frequent and uncommon T-cell lymphoma subtypes.
  • To pool prospective data globally for a comprehensive analysis of TCLs.

Main Methods:

  • Prospective data collection from multiple international centers.
  • Enrollment of adult patients with untreated, de novo peripheral T-cell lymphoma (PTCL) or natural killer (NK)/T-cell lymphoma.
  • Validation of patient cases and evaluation of treatment responses, progression-free survival, and overall survival.

Main Results:

  • As of October 2009, 479 patients were enrolled from 13 centers, with 454 validated cases.
  • Analysis focused on treatment efficacy and patient survival metrics.
  • Data collection aimed at characterizing diverse TCL subtypes.

Conclusions:

  • The T-Cell Project is establishing a valuable global dataset for TCL research.
  • Findings will contribute to a better understanding of TCL biology and treatment strategies.
  • This collaborative effort is crucial for advancing the care of patients with these rare lymphomas.