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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

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Published on: June 16, 2020

[Paraneoplastic sclerodermiform syndrome].

A Hounkpati¹, I Marie, D Paillotin

¹Service de pneumologie et unité de soins intensifs respiratoires, université de Rouen, hôpital de Bois-Guillaume, CHU de Rouen, UPRES EA 3830 (IFR MP23), institut hospitalo-universitaire de recherche biomédicale, 76031 Rouen cedex, France. frederic.hounkpati@chu-rouen.fr

Revue Des Maladies Respiratoires

|April 3, 2010

Summary

Sclerodermiform syndrome, a skin condition, may indicate underlying cancer. This case showed rapid skin lesion improvement after cancer treatment, suggesting its inclusion in scleroderma classifications.

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Area of Science:

Rheumatology
Oncology
Dermatology

Background:

Systemic sclerosis classifications lack clear criteria for paraneoplastic or cancer treatment-related sclerodermiform syndromes.
The association between scleroderma and cancer is recognized but not fully integrated into classification systems.

Observation:

A 56-year-old male presented with severe Raynaud's phenomenon and digital necrosis.
Diagnostic workup revealed bronchial adenocarcinoma, treated with chemotherapy and lobectomy.
Skin lesions significantly improved after two cycles of neoadjuvant chemotherapy.

Findings:

The case highlights a potential paraneoplastic sclerodermiform syndrome.
Rapid resolution of skin lesions following antineoplastic treatment was observed.
Negative anticentromere and anti-topoisomerase 1 antibodies in the presence of high antinuclear antibodies.

Implications:

Sclerodermiform syndrome can be an early indicator of an underlying neoplasm.
Inclusion of sclerodermiform syndrome in systemic sclerosis classification is proposed.
This case underscores the importance of considering malignancy in patients with sclerodermiform presentations.