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Related Concept Videos

Other Disorders of Digestive System01:30

Other Disorders of Digestive System

The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
Gastritis II: Pathophysiology01:26

Gastritis II: Pathophysiology

The pathophysiology of gastritis begins with the colonization of the stomach lining by Helicobacter pylori (H. pylori). This bacterium spreads mainly via the oral-oral route through saliva or shared utensils, and can also be transmitted in overcrowded or unhygienic environments through contaminated water, despite its brief survival outside the body.ColonizationOnce ingested, H. pylori enters the stomach and begins colonization by navigating through the mucus layer lining the stomach wall. It...

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Related Experiment Video

Updated: Jun 14, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

[Celiac disease].

G Malamut1, C Cellier

  • 1Université Paris Descartes, 75006 Paris, France. georgia.malamut@egp.aphp.fr

La Revue De Medecine Interne
|April 3, 2010
PubMed
Summary
This summary is machine-generated.

Celiac disease is an autoimmune disorder triggered by gluten in genetically susceptible individuals. A strict gluten-free diet is the primary treatment, preventing serious complications like cancer and bone disease.

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Basic Three-Dimensional (3D) Intestinal Model System with an Immune Component
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Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
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Basic Three-Dimensional (3D) Intestinal Model System with an Immune Component
07:39

Basic Three-Dimensional (3D) Intestinal Model System with an Immune Component

Published on: September 1, 2023

Area of Science:

  • Gastroenterology
  • Immunology
  • Genetics

Context:

  • Celiac disease affects approximately 1% of the population in Europe and the USA.
  • It is an enteropathy triggered by gluten ingestion in genetically predisposed individuals (HLA DQ2/DQ8).
  • Clinical presentations are diverse, including anemia, oral ulcers, amenorrhea, and joint pain.

Purpose:

  • To outline the diagnostic criteria for celiac disease.
  • To emphasize the importance of a gluten-free diet in management.
  • To discuss complications and therapeutic challenges.

Summary:

  • Diagnosis requires histological evidence of villous atrophy in the small intestine and specific serum antibodies.
  • Treatment involves complete gluten (wheat, barley, rye) exclusion from the diet.
  • Adherence to a gluten-free diet prevents malignant complications like adenocarcinoma, lymphoma, and osteopenia.

Impact:

  • Effective management with a gluten-free diet prevents severe long-term health issues.
  • Challenges include poor adherence and the need for alternative treatments for refractory cases.
  • Further research is needed for alternative therapies and managing lymphomatous complications.