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Related Experiment Video

Updated: Jun 14, 2026

Hickman Catheter Use for Long-Term Vascular Access in a Preclinical Swine Model

Hickman Catheter Use for Long-Term Vascular Access in a Preclinical Swine Model

Published on: March 31, 2023

A healthy man with intractable hiccups.

Ioannis Pechlivanis¹, Marcel Seiz, Martin Barth

¹Department of Neurosurgery, University Hospital Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68135 Mannheim, Germany. ioannis.pechlivanis@umm.de

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia

|April 3, 2010

Summary

Intractable hiccups, often debilitating, can signal underlying brainstem lesions. Surgical removal of a rhomboid fossa cavernoma resolved a patient's persistent hiccups, demonstrating a link between intracranial pathology and this symptom.

Related Experiment Videos

Last Updated: Jun 14, 2026

Hickman Catheter Use for Long-Term Vascular Access in a Preclinical Swine Model

Hickman Catheter Use for Long-Term Vascular Access in a Preclinical Swine Model

Published on: March 31, 2023

Area of Science:

Neurology
Neurosurgery
Pathology

Background:

Intractable hiccups are a challenging clinical problem.
Medical management often provides only partial relief.
Gastrointestinal causes are frequently investigated but may not be the source.

Observation:

A patient presented with persistent hiccups refractory to medical treatment.
Cranial MRI identified a small lesion in the right rhomboid fossa near the vagal trigone.
The lesion was surgically resected via suboccipital median craniotomy.

Findings:

Histopathological analysis confirmed the lesion as a cavernoma.
The patient experienced complete resolution of hiccups immediately following microsurgical resection.
This case highlights the potential association between brainstem lesions and intractable hiccups.

Implications:

Intracranial pathologies, particularly brainstem lesions, should be considered in cases of intractable hiccups.
Microsurgical resection can be an effective treatment for hiccups caused by specific intracranial lesions.
Early diagnosis and surgical intervention may significantly improve patient outcomes for this debilitating symptom.