New tools for detecting occult monoclonal gammopathy, a cause of secondary osteoporosis
1Taussig Cancer Institute, R33, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA. faimanb@ccf.org
Cleveland Clinic Journal of Medicine
|April 3, 2010
Abstract:
Most patients with multiple myeloma or other monoclonal gammopathies present with anemia, hypercalcemia, or renal insufficiency. However, osteoporosis may be the first sign. Measuring the concentration and ratio of free light chains in the serum can help detect monoclonal gammopathy and help to differentiate myeloma-related bone loss from other secondary forms of osteoporosis.