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Fentanyl Analog Screening using LC-TIMS-TOF MS/MS

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Fatal nefopam overdose.

Deborah E Kerr¹, Alan K Fletcher

¹Emergency Department, Northern General Hospital, Sheffield, UK. debbiekerr@doctors.org.uk

Emergency Medicine Journal : EMJ

|April 3, 2010

Summary

This summary is machine-generated.

Nefopam overdose can be fatal, leading to cardiac arrest. This case report highlights the severe risks associated with intentional nefopam (Acupan) overdose, emphasizing its potential for lethal outcomes.

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Area of Science:

Pharmacology
Toxicology
Emergency Medicine

Background:

Nefopam hydrochloride (Acupan) is a non-opioid analgesic for moderate to severe pain.
It is generally well-tolerated but has known side effects and overdose risks.

Observation:

A previously healthy 19-year-old man presented with cardiac arrest after intentional nefopam overdose.
This represents the fourth reported case of fatal nefopam overdose in medical literature.

Findings:

Nefopam overdose can precipitate severe cardiac conduction abnormalities.
Potential complications include cerebral edema, fever, and renal failure.

Implications:

This case underscores the critical need for awareness regarding nefopam's toxicity in overdose scenarios.
Highlights the importance of prompt medical intervention for suspected nefopam toxicity.