Related Experiment Video
Updated: Jun 14, 2026

Fentanyl Analog Screening using LC-TIMS-TOF MS/MS
Published on: November 8, 2024
Fatal nefopam overdose
Deborah E Kerr1, Alan K Fletcher
1Emergency Department, Northern General Hospital, Sheffield, UK. debbiekerr@doctors.org.uk
Abstract:
Nefopam hydrochloride (Acupan) is a potent non-opioid analgesic widely used for the relief of moderate to severe postoperative pain. The drug is generally well tolerated, but it has a broad spectrum of side effects including tachycardia, sweating, nausea, seizures and hallucinations. When taken in overdose, nefopam has been reported to cause cardiac conduction abnormalities, cerebral oedema, fever and renal failure. The case is presented of a previously healthy 19-year-old man who presented to the emergency department in cardiac arrest following intentional nefopam overdose. It is only the fourth reported case of fatal nefopam overdose in the literature.
Related Concept Videos
Opioid Analgesics: Synthetic and Semisynthetic Opioids
Pharmaceutical Poisoning: Treatment Strategies
Pharmaceutical Poisoning: Potential Scenarios
Drug Toxicity: Overview
Drug Toxicity: Dose-Dependent Reactions
Drug Toxicity: Risk factors
