Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparison of [<sup>18</sup>F]DPA-814 with [<sup>18</sup>F]DPA-714 for TSPO Imaging in an Experimental Model.

Molecular imaging and biology·2026
Same author

Decreased mebrofenin uptake in patients with non-colorectal liver tumors requiring liver volume augmentation-a single-center analysis.

Langenbeck's archives of surgery·2024
Same author

Denoising non-steady state dynamic PET data using a feed-forward neural network.

Physics in medicine and biology·2020
Same author

Performance evaluation of a novel multi-pinhole collimator for dopamine transporter SPECT.

Physics in medicine and biology·2020
Same author

Imaging disease activity of rheumatoid arthritis by macrophage targeting using second generation translocator protein positron emission tomography tracers.

PloS one·2019
Same author

A new setup for the quantitative analysis of drying by the use of gas-phase FTIR-spectroscopy.

The Review of scientific instruments·2018

Related Experiment Video

Updated: Jun 14, 2026

Non-invasive Imaging and Analysis of Cerebral Ischemia in Living Rats Using Positron Emission Tomography with 18F-FDG
10:31

Non-invasive Imaging and Analysis of Cerebral Ischemia in Living Rats Using Positron Emission Tomography with 18F-FDG

Published on: December 28, 2014

Attenuation correction for the large non-human primate brain imaging using microPET.

S Naidoo-Variawa1, W Lehnert, M Kassiou

  • 1Discipline of Medical Radiation Sciences, Faculty of Health Sciences, University of Sydney, PO Box 170, Lidcombe, NSW 1825, Sydney, Australia. snai3212@uni.sydney.edu.au

Physics in Medicine and Biology
|April 3, 2010
PubMed
Summary

Accurate attenuation correction is crucial for baboon brain imaging using microPET scanners. Measured correction with Cobalt-57 or Germanium-68 sources offers the best balance of accuracy and image quality for CNS radioligand studies.

More Related Videos

A MRI-Based Toolbox for Neurosurgical Planning in Nonhuman Primates
08:41

A MRI-Based Toolbox for Neurosurgical Planning in Nonhuman Primates

Published on: July 17, 2020

A Neural Implant Design Toolbox for Nonhuman Primates
06:33

A Neural Implant Design Toolbox for Nonhuman Primates

Published on: February 9, 2024

Related Experiment Videos

Last Updated: Jun 14, 2026

Non-invasive Imaging and Analysis of Cerebral Ischemia in Living Rats Using Positron Emission Tomography with 18F-FDG
10:31

Non-invasive Imaging and Analysis of Cerebral Ischemia in Living Rats Using Positron Emission Tomography with 18F-FDG

Published on: December 28, 2014

A MRI-Based Toolbox for Neurosurgical Planning in Nonhuman Primates
08:41

A MRI-Based Toolbox for Neurosurgical Planning in Nonhuman Primates

Published on: July 17, 2020

A Neural Implant Design Toolbox for Nonhuman Primates
06:33

A Neural Implant Design Toolbox for Nonhuman Primates

Published on: February 9, 2024

Area of Science:

  • Nuclear medicine
  • Primate neuroimaging
  • Radiopharmaceutical biodistribution

Background:

  • Baboon brains closely resemble human brains, making them ideal models for central nervous system (CNS) radioligand evaluation.
  • Accurate in vivo assessment of radiopharmaceuticals in animal models is essential before human trials.
  • Previous work established the feasibility of baboon brain imaging on small animal PET scanners with proper attenuation correction.

Purpose of the Study:

  • To investigate factors influencing the accuracy and reliability of attenuation correction strategies for primate brain imaging.
  • To compare different measured attenuation correction methods using Cobalt-57 and Germanium-68 transmission sources on a microPET scanner.
  • To evaluate the impact of acquisition time and energy window settings on image quality.

Main Methods:

  • Utilized a microPET Focus 220 scanner to image the brain of a baboon (Papio hamadryas).
  • Compared measured attenuation correction using (57)Co and (68)Ge transmission sources with varying energy windows and acquisition times.
  • Assessed segmented attenuation correction based on uncorrected emission images.
  • Evaluated bias-noise trade-offs and signal-to-noise ratio (SNR) in corrected images, including an [(18)F]FDG brain scan.

Main Results:

  • The optimal energy window for (57)Co was 4%, and for (68)Ge in singles mode was 20%, yielding the best bias-noise performance.
  • Increasing acquisition time minimally impacted the bias-noise trade-off for corrected images.
  • Measured attenuation correction strategies provided good results and similar SNR, while segmented correction introduced regional bias in deep brain structures and the skull.

Conclusions:

  • Measured attenuation correction using (57)Co or (68)Ge transmission scans provides an excellent balance between bias and noise propagation for primate brain microPET imaging.
  • These methods are reliable for evaluating novel CNS radioligands in baboon models.
  • Segmented attenuation correction is less suitable for primate brain imaging due to introduced biases.