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Update on the medical treatment of Graves' ophthalmopathy
Gregory J Griepentrog1, James A Garrity
1Department of Ophthalmology, Mayo Clinic, Rochester, MN, USA.
Purpose:
To review recent advances in the understanding of Graves' ophthalmopathy (GO) pathogenesis as well as discuss current and future medical management strategies.
Design:
Interpretive essay.
Methods:
Literature review and interpretation.
Results:
Medical treatment of GO has slowly evolved during the past few decades and has been hampered by a poor understanding of the disease at a cellular and molecular level. Current treatment recommendations and guidelines therefore focus on nonspecific immuno-suppression. Newer classes of treatment agents hold promise to more selectively target underlying cellular and molecular alterations in GO.
Conclusion:
Cooperation between individual patients, physicians and between differing medical centers, together with a refined understanding of the pathogenesis of GO, will lead to newer more-effective treatments for the disease and improve patient quality of life.
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