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Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

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Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Published on: September 7, 2013

Primary cutaneous melanoma: an 18-year study.

Moris Anger¹, Henri Friedhofer, Marina Fussae Fukutaki

¹Plastic Surgery Service, Brigadeiro Hospital - São Paulo/SP, Brazil. morisanger@terra.com.br

Clinics (Sao Paulo, Brazil)

|April 3, 2010

Summary

Melanoma incidence is rising, particularly in sun-exposed areas. Mitotic rate, Breslow thickness, and ulceration are key prognostic factors for cutaneous melanoma.

Keywords:

Epidemiology Melanoma Prognosis Risk factors Skin neoplasm

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Area of Science:

Dermatology
Oncology
Pathology

Background:

Primary cutaneous melanoma is a significant cause of skin cancer mortality.
Incidence rates of melanoma are steadily increasing globally.

Purpose of the Study:

To evaluate clinical, epidemiological, and demographic aspects of cutaneous melanoma.
To correlate these factors with patient prognosis.

Main Methods:

Analysis of clinical and epidemiological data from 84 primary cutaneous melanoma patients (1990-2007).
Histopathological examination of surgical specimens, including analysis of Breslow thickness, ulceration, and mitotic rate.

Main Results:

Melanoma incidence higher in sun-exposed areas; common sites include trunk (males) and lower limbs (females).
Breslow thickness, ulceration, and mitotic rate are significant prognostic indicators (p=0.043, p<0.001, p=0.0007 respectively).
A prognostic score combining ulceration, Breslow index, and mitotic index predicted systemic disease in 91.7% of patients with a score of three or higher; 5-year survival was approximately 70%.

Conclusions:

Mitotic rate is an important prognostic factor for cutaneous melanoma, aligning with upcoming TNM staging updates.
The proposed prognostic score warrants further investigation for clinical utility.